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Extracellular Superoxide Dismutase Protects Cardiomyocytes During Hyperoxia, Mervat Elsayed Ali
Extracellular Superoxide Dismutase Protects Cardiomyocytes During Hyperoxia, Mervat Elsayed Ali
Theses and Dissertations in Biomedical Sciences
Reactive oxygen species are implicated in tissue damage in many cardiovascular diseases. The current study was designed to test the hypothesis that exposure to high inspired oxygen concentrations (100%) damages cardiac mitochondria and that a biogenic response is needed for cell survival. The study was done in mice with a transgene (TG) for extracellular superoxide dismutase (EC-SOD) or with the EC-SOD gene knockout (KO). Adult EC-SOD mice and their wild type littermates and EC-SOD KO mice and their wild type littermates were exposed to 100% oxygen for 6 hours and for 72 hours, and the hearts were subsequently removed under …