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Characterization Of Alternative Cytosolic Forms And Cellular Targets Of Mouse Mitochondrial Thioredoxin Reductase, Anton A. Turanov, Dan Su, Vadim N. Gladyshev
Characterization Of Alternative Cytosolic Forms And Cellular Targets Of Mouse Mitochondrial Thioredoxin Reductase, Anton A. Turanov, Dan Su, Vadim N. Gladyshev
Vadim Gladyshev Publications
Thioredoxin reductase (TR) and thioredoxin (Trx) define a major cellular redox system that maintains cysteine residues in numerous proteins in the reduced state. Both cytosolic (TR1 and Trx1) and mitochondrial (TR3 and Trx2) enzymes are essential in mammals, but the function of the mitochondrial system is less understood. In this study, we characterized subcellular localization of three TR3 forms that are generated by alternative first exon splicing and that differ in their N-terminal sequences. Only one of these forms resides in mitochondria, whereas the two other isoforms are cytosolic. Consistent with this finding, TR3 did not have catalytic preferences for …