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Biochemical Profiling Of Gout Patients, Tamera Fayre Schlitt
Biochemical Profiling Of Gout Patients, Tamera Fayre Schlitt
Chemistry & Biochemistry Theses & Dissertations
The purpose of the research is to investigate the biochemical cause of gout in 82 patients. The gouty patients had been diagnosed with gout according to the criterion of the American Rheumatism Association. This gout patient population consisted of 58 men and 24 women with gout whose ages ranged from 11 to 84 years of age with a mean age of 44 years. Key purine metabolism enzyme activity levels and purine metabolite concentrations in the patients' plasma and urine were compared to the mean values of a healthy control group. The control group consisted of 33 males and 25 female …
Development Of Single Nanoparticle Optical Assays For Imaging Single Living Cells, William John Brownlow
Development Of Single Nanoparticle Optical Assays For Imaging Single Living Cells, William John Brownlow
Chemistry & Biochemistry Theses & Dissertations
Multi-drug resistance (MDR) has been reported in both prokaryotes and eukaryotes; the pathogenic gram-negative bacteria Pseudomonas aeruginosa can extrude a variety of structurally and functionally diverse substrates via a number of membrane transport systems leading to MDR. We have developed a novel nanoparticle assay to characterize both the membrane transport system composed of the MexAB-OprM efflux pump and the membrane permeability induced by antibiotics. Gold (Au) and silver (Ag) nanoparticles were investigated for use as probes to explore membrane transport in P. aeruginosa.
The surface plasmon absorption (color) of Au nanoparticle solutions was found to change in the presence …