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Full-Text Articles in Life Sciences
Vitronectin And Plasminogen Activator Inhibitor-1 Form Higher-Order Complexes That Localize To The Extracellular Matrix And Adopt Adhesive Properties, Kenneth H. Minor
Vitronectin And Plasminogen Activator Inhibitor-1 Form Higher-Order Complexes That Localize To The Extracellular Matrix And Adopt Adhesive Properties, Kenneth H. Minor
Doctoral Dissertations
Vitronectin is a human circulatory protein that is recruited to the extracellular matrix (ECM) during tissue remodeling pathways linked to injury, inflammation, and tumor metastasis. Whereas circulating vitronectin is monomeric, the tissue-associated form is multimeric and contains multivalent binding sites for both cell-surface receptors and components of the extracellular matrix. In addition, matrix-associated vitronectin directly regulates plasmin-regulated matrix proteolysis through the localization and stabilization of the serine protease inhibitor, plasminogen activator inhibitor type-1 (PAI-1). As a component of the ECM, vitronectin adopts a pro-adhesive role, providing a unique regulatory link between cell adhesion and pericellular proteolysis. The mechanism by which …
Ethylene Stimulates Nutations That Are Dependent On The Etr1 Receptor, Brad M. Binder, Ronan C. O'Malley, Wuyi Wang, Tobias C. Zutz, Anthony B. Bleeker
Ethylene Stimulates Nutations That Are Dependent On The Etr1 Receptor, Brad M. Binder, Ronan C. O'Malley, Wuyi Wang, Tobias C. Zutz, Anthony B. Bleeker
Faculty Publications and Other Works -- Biochemistry, Cellular and Molecular Biology
Ethylene influences a number of processes in Arabidopsis (Arabidopsis thaliana) through the action of five receptors. In this study, we used high-resolution, time-lapse imaging to examine the long-term effects of ethylene on growing, etiolated Arabidopsis seedlings. These measurements revealed that ethylene stimulates nutations of the hypocotyls with an average delay in onset of over 6 h. The nutation response was constitutive in ctr1-2 mutants maintained in air, whereas ein2-1 mutants failed to nutate when treated with ethylene. Ethylene-stimulated nutations were also eliminated in etr1-7 loss-of-function mutants. Transformation of the etr1-7 mutant with a wild-type genomic ETR1 transgene rescued the nutation …
Soluble Fibrin Inhibits Monocyte Adherence And Cytotoxicity Against Tumor Cells: Implications For Cancer Metastasis, John Biggerstaff, Brandy Weidow, Jacqueline Vidosh, Judith Dexheimer, Shonak Patel, Pretesh Patel
Soluble Fibrin Inhibits Monocyte Adherence And Cytotoxicity Against Tumor Cells: Implications For Cancer Metastasis, John Biggerstaff, Brandy Weidow, Jacqueline Vidosh, Judith Dexheimer, Shonak Patel, Pretesh Patel
Faculty Publications and Other Works -- Biochemistry, Cellular and Molecular Biology
Background Soluble fibrin (sFn) is a marker for disseminated intravascular coagulation and may have prognostic significance, especially in metastasis. However, a role for sFn in the etiology of metastatic cancer growth has not been extensively studied. We have reported that sFn cross-linked platelet binding to tumor cells via the major platelet fibrin receptor αIIbβ3, and tumor cell CD54 (ICAM-1), which is the receptor for two of the leukocyte β2 integrins (αLβ2 and aMβ2). We hypothesized that sFn may also affect leukocyte adherence, recognition, and killing of tumor cells. Furthermore, in a rat experimental metastasis model sFn pre-treatment of tumor cells …