Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Actins (1)
- Alternative Splicing (1)
- Amino Acid (1)
- Amino Acid Sequence (1)
- B cell (1)
-
- B lymphoma cells (1)
- Cell Adhesion (1)
- Cell Differentiation (1)
- Cell Line, Tumor (1)
- Ciona intestinalis (1)
- Cloning (1)
- Cloning, Molecular (1)
- Down-Regulation (1)
- Early Growth Response Protein 1 (1)
- Egr-1 (1)
- Extracellular Signal-Regulated MAP Kinases (1)
- Female (1)
- Growth Inhibitors (1)
- HeLa Cells (1)
- Humans (1)
- JNK Mitogen-Activated Protein Kinases (1)
- Lymphoma, B-Cell (1)
- MAP Kinase Signaling System (1)
- MAPKs (1)
- Mice (1)
- Mice, Inbred BALB C (1)
- Mice, Inbred CBA (1)
- Molecular (1)
- Molecular Sequence Data (1)
Articles 1 - 2 of 2
Full-Text Articles in Life Sciences
Evidence That Talin Alternative Splice Variants From Ciona Intestinalis Have Different Roles In Cell Adhesion, Richard H. Singiser, Richard O. Mccann
Evidence That Talin Alternative Splice Variants From Ciona Intestinalis Have Different Roles In Cell Adhesion, Richard H. Singiser, Richard O. Mccann
Molecular and Cellular Biochemistry Faculty Publications
BACKGROUND: Talins are large, modular cytoskeletal proteins found in animals and amoebozoans such as Dictyostelium discoideum. Since the identification of a second talin gene in vertebrates, it has become increasingly clear that vertebrate Talin1 and Talin2 have non-redundant roles as essential links between integrins and the actin cytoskeleton in distinct plasma membrane-associated adhesion complexes. The conserved C-terminal I/LWEQ module is important for talin function. This structural element mediates the interaction of talins with F-actin. The I/LWEQ module also targets mammalian Talin1 to focal adhesion complexes, which are dynamic multicomponent assemblies required for cell adhesion and cell motility. Although Talin1 is …
The Role Of Mapks In B Cell Receptor-Induced Down-Regulation Of Egr-1 In Immature B Lymphoma Cells, Jiyuan Ke, Murali Gururajan, Anupam Kumar, Alan Simmons, Lilia Turcios, Ralph Lakshman Chelvarajan, David M. Cohen, David L. Wiest, John G. Monroe, Subbarao Bondada
The Role Of Mapks In B Cell Receptor-Induced Down-Regulation Of Egr-1 In Immature B Lymphoma Cells, Jiyuan Ke, Murali Gururajan, Anupam Kumar, Alan Simmons, Lilia Turcios, Ralph Lakshman Chelvarajan, David M. Cohen, David L. Wiest, John G. Monroe, Subbarao Bondada
Microbiology, Immunology, and Molecular Genetics Faculty Publications
Cross-linking of the B cell receptor (BCR) on the immature B lymphoma cell line BKS-2 induces growth inhibition and apoptosis accompanied by rapid down-regulation of the immediate-early gene egr-1. In these lymphoma cells, egr-1 is expressed constitutively and has a prosurvival role, as Egr-1-specific antisense oligonucleotides or expression of a dominant-negative inhibitor of Egr-1 also prevented the growth of BKS-2 cells. Moreover, enhancement of Egr-1 protein with phorbol 12-myristate 13-acetate or an egr-1 expression vector rescued BKS-2 cells from BCR signal-induced growth inhibition. Nuclear run-on and mRNA stability assays indicated that BCR-derived signals act at the transcriptional level to …