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Full-Text Articles in Life Sciences
The Role Of Trailerhitch In Mouse Germ Cell Development, Ashley L. O'Hara
The Role Of Trailerhitch In Mouse Germ Cell Development, Ashley L. O'Hara
Honors Capstone Projects - All
During oogenesis in the Drosophila ovary, a 16-cell cyst develops in which one cell grows to become the oocyte. The surrounding nurse cells transport mRNAs, proteins, and organelles to the oocyte during development and must be localized properly within the oocyte. A complex of proteins is responsible for mRNA localization, including the recently discovered protein Trailerhitch. Homologs of Trailerhitch exist in other species including C. elegans, yeast, mice, and humans, but the function is unknown. We are interested in studying the function of Trailerhitch in mouse germ cell development. Mice with a nonfunctional Trailerhitch gene were synthesized using a gene …
The Response Of A Biocompatible Liquid Crystal To Ions And Chemistry On Nanostructured Surfaces, Anny Huang
The Response Of A Biocompatible Liquid Crystal To Ions And Chemistry On Nanostructured Surfaces, Anny Huang
Honors Capstone Projects - All
Traditional lyotropic liquid crystals are composed of amphiphilic molecules forming assemblies in water. Disodium cromoglycate (cromolyn or DSCG) – an antiasthmatic drug – is a novel and unusual lyotropic liquid crystal because it is not amphiphilic, and yet, it exhibits large birefringence (shininess) when dissolved in water forming lyotropic liquid crystal. In the work, DSCG liquid crystal is doped with different types of salt such as sodium chloride and sodium perchlorate, and the response in the changes of birefringence and liquid crystal transition temperature is studied. We find that addition of certain type of salts enhance the propensity of formation …
A Sensitive Subject: Haploinsufficiency Of The Yeast Vma13 Gene In Simple And Compound Heterozygotes, Jason Michael Rizzo
A Sensitive Subject: Haploinsufficiency Of The Yeast Vma13 Gene In Simple And Compound Heterozygotes, Jason Michael Rizzo
Honors Capstone Projects - All
Vacuolar-proton translocating-ATPases (V-ATPases) are the membranebound transporters responsible for controlling pH levels in intracellular compartments. The V-ATPase enzyme is a multi-subunit complex consisting of two distinct domains, a cytosolic V1 region and a membrane-bound Vo domain. While the interface between V1 and Vo is not as well understood, studies suggest the possibility of multiple peripheral stalks tethering the complex. In response to glucose deprivation, the V1 and Vo sectors of the enzyme are capable of dissociating into separate, and inactive, domains as a means of regulation. At least 4 V1 subunits (C, H, E, and G) are believed to form …
Total Synthesis Of Pumiliotoxin 341a, Lydia Choi
Total Synthesis Of Pumiliotoxin 341a, Lydia Choi
Honors Capstone Projects - All
Pumiliotoxin 341 A differs from all other pumiliotoxins in that its alkylidene side chain has been cyclized to form a pyranose ring, providing another quaternary center in its indolizidine ring. Although the gross structure of this natural product has been determined, the absolute and relative stereochemistry of the tertiary alcohol on C14 is still unknown. As a result, we want to synthesize this alkaloid to prove its stereochemistry and to prepare material for further biological analysis. A rhodium-catalyzed alkyne addition reaction currently being developed in our group is employed as the key reaction in our synthesis of the indolizidine core. …