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Endocrine Responses To Chronic Androstenedione Intake In 30- To 56-Year-Old Men, Gregory A. Brown, Matthew D. Vukovich, Emily R. Martini, Marian L. Kohut, Warren D. Franke, David A. Jackson, Douglas S. King
Endocrine Responses To Chronic Androstenedione Intake In 30- To 56-Year-Old Men, Gregory A. Brown, Matthew D. Vukovich, Emily R. Martini, Marian L. Kohut, Warren D. Franke, David A. Jackson, Douglas S. King
Warren D Franke
In young men, chronic ingestion of 100 mg androstenedione (ASD), three times per day, does not increase serum total testosterone but does increase serum estrogen and ASD concentrations. We investigated the effects of ASD ingestion in healthy 30- to 56-yr-old men. In a double-blind, randomly assigned manner, subjects consumed 100 mg ASD three times daily (n 5 28), or placebo (n 5 27) for 28 days. Serum ASD , dihydrotestosterone (DHT), free and total testosterone, estradiol, prostate-specific antigen (PSA), and lipid concentrations were measured at week 0 and each week throughout the supplementation period. Serum total testosterone and PSA concentrations …