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Genomic And Experimental Evidence For Multiple Metabolic Functions In The Rida/Yjgf/Yer057c/Uk114 (Rid) Protein Family, Thomas D. Niehaus, Svetlana Gerdes, Kelsey Hodge-Hanson, Aleksey Zhukov, Arthur J L Cooper, Mona Elbadawi-Sidhu
Genomic And Experimental Evidence For Multiple Metabolic Functions In The Rida/Yjgf/Yer057c/Uk114 (Rid) Protein Family, Thomas D. Niehaus, Svetlana Gerdes, Kelsey Hodge-Hanson, Aleksey Zhukov, Arthur J L Cooper, Mona Elbadawi-Sidhu
NYMC Faculty Publications
BACKGROUND: It is now recognized that enzymatic or chemical side-reactions can convert normal metabolites to useless or toxic ones and that a suite of enzymes exists to mitigate such metabolite damage. Examples are the reactive imine/enamine intermediates produced by threonine dehydratase, which damage the pyridoxal 5'-phosphate cofactor of various enzymes causing inactivation. This damage is pre-empted by RidA proteins, which hydrolyze the imines before they do harm. RidA proteins belong to the YjgF/YER057c/UK114 family (here renamed the Rid family). Most other members of this diverse and ubiquitous family lack defined functions.
RESULTS: Phylogenetic analysis divided the Rid family into a …