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Synergistic Mixtures Of Fungitoxic Monochloro And Dichloro-8-Quinolinols Against Five Fungi / Herman Gershon, Muriel Gershon, & Donald D. Clarke Harding Laboratory, The New York Botanical Garden, Bronx, Ny 10458-5126, Usa; Department Of Chemistry, Fordham University, Bronx, Ny 10458-9993, Usa, Herman Gershon, Muriel Gershon, Donald Dudley Clarke Phd
Synergistic Mixtures Of Fungitoxic Monochloro And Dichloro-8-Quinolinols Against Five Fungi / Herman Gershon, Muriel Gershon, & Donald D. Clarke Harding Laboratory, The New York Botanical Garden, Bronx, Ny 10458-5126, Usa; Department Of Chemistry, Fordham University, Bronx, Ny 10458-9993, Usa, Herman Gershon, Muriel Gershon, Donald Dudley Clarke Phd
Chemistry Faculty Publications
Fourteen mono- and dichloro-8-quinolinols were tested against five fungi (Aspergillus niger, A. oryzae, Myrothecium verrucaria, Trichoderma viride, and Mucor circinelloides) and compared with the fungitoxicity of 8- quinolinol in Yeast Nitrogen Base containing l% D-glucose and 0.088% L-asparagine. All of the compounds were more fungitoxic than 8-quinolinol except for the surprising activity of 8-quinolinol against A. oryzae. Mixtures of the MICs of monochloro- and dichloro-8-quinolinols in which the halogens were in different positions of the quinoline ring showed synergism. Comparable mixtures in which one position of each compound was occupied by the same halogen showed additive activity. In a different …
Preparation And Fungitoxicity Of Some Dichloro-8-Quinolinols / Herman Gershon, Donald D. Clarke, And Muriel Gershon Department Of Chemistry, Fordham University, Bronx, Ny 10458, Usa New York Botanical Garden, Bronx, Ny 10458, Usa, Herman Gershon, Donald Dudley Clarke Phd, Muriel Gershon
Preparation And Fungitoxicity Of Some Dichloro-8-Quinolinols / Herman Gershon, Donald D. Clarke, And Muriel Gershon Department Of Chemistry, Fordham University, Bronx, Ny 10458, Usa New York Botanical Garden, Bronx, Ny 10458, Usa, Herman Gershon, Donald Dudley Clarke Phd, Muriel Gershon
Chemistry Faculty Publications
2,5-, 3,5-, 3,7-, 4,5-, 5,6-, und 6,7-Dichloro-8-quinolinols were prepared and tested along with their 3,6- and 5,7-ana1ogues against six fungi (Aspergillus niger, A. oryzae, Myrothecium verrucaria, Trichoderma viride, Mucor cirinelloides, and Trichophyton mentagrophytes) in Sabouraud dextrose broth. Most of the compounds were strongly antifungal, inhibiting five of the fungi below 1 μg/ml. This activity is attributed to intramolecular synergism. M. cirinelloides was inhibited less by these compounds