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Fluoroacetate And Fluorocitrate: Mechanism Of Action / Donald D. Clarke, Donald Dudley Clarke Phd
Fluoroacetate And Fluorocitrate: Mechanism Of Action / Donald D. Clarke, Donald Dudley Clarke Phd
Chemistry Faculty Publications
The concept of lethal synthesis as suggested by Peters is reviewed in the light of the more recent work in this area. It is suggested that fluorocitrate is a "suicide" substrate for aconitase rather than a competitive inhibitor as originally suggested. The use of these substances to study glialneuronal relationships is considered