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Identification And Characterization Of Candidate Staphylococcus Aureus Antigens For Inclusion In A Multivalent Bovine Mastitis Vaccine, Danielle Scarbrough

Boise State University Theses and Dissertations

Bovine mastitis, inflammation typically caused by bacterial infection, is the most prevalent disease affecting the global dairy industry. Staphylococcus aureus remains one of the most important pathogens implicated in the disease and can persist within herds at subclinical levels. A preventative S. aureus bovine mastitis vaccine would substantially lessen costs associated with treatment and restore revenue lost due to decreased milk production. One such experimental vaccine is the IsdA-CTA₂/B + ClfA-CTA₂/B vaccine, containing the S. aureus antigens IsdA and ClfA , each fused to the nontoxic A₂/B subunits of cholera toxin, which serves as …