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Developing Sodium Mri For Longitudinal Assessment Of Chemotherapy Of Glioma In A Rat Model Of Cancer, Xin Yue Wang

Electronic Thesis and Dissertation Repository

Glioblastoma (GBM) is an aggressive cancer which presents significant challenges for disease management and treatment. Tissue sodium concentration (TSC) is a sensitive indicator of disease and changes in TSC can be used as a potential biomarker for treatment response. A longitudinal orthotopic C6 GBM model was used to study changes in TSC due to cancer. Animals were imaged with contrast enhanced T₁-weighted, T₂-weighted and sodium MRI and were either un-treated or received temozolomide (TMZ) treatment. Accurate assessment of TSC was possible for tumour volumes greater than 150mm³ using 3mm isotropic imaging voxels. TSC increased with …