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Full-Text Articles in Life Sciences
Investigating The Effects Of Particulate Hexavalent Chromium On The Centriole Linkers, Julieta Martino
Investigating The Effects Of Particulate Hexavalent Chromium On The Centriole Linkers, Julieta Martino
Electronic Theses and Dissertations
Particulate hexavalent chromium (Cr(VI)) compounds are human lung carcinogens. However, their carcinogenicity is poorly understood. The best model for Cr(VI)-induced carcinogenesis involves the acquisition of structural and numerical chromosome instability (CIN). Many mechanisms contribute to CIN. Among these, centrosomes play a pivotal role because they dictate proper segregation of chromosomes during cell division. Cr(VI) causes centrosome amplification, a phenotype where cells have extra centrosomes and hence can undergo unequal distribution of chromosomes resulting in CIN. How Cr(VI) induces these abnormalities is unknown. Moreover, whether Cr(VI)-induced centrosome amplification is a permanent phenotypic change is also unknown. This work investigates the permanence …
Complete Annotations Of The Cluster E Mycobacteriophage Ukulele Genome And Characterization Of Cluster E Lysogeny Regulation, Gwendolyn M. Beacham
Complete Annotations Of The Cluster E Mycobacteriophage Ukulele Genome And Characterization Of Cluster E Lysogeny Regulation, Gwendolyn M. Beacham
Honors College
Mycobacteriophages (phages) are diverse and abundant viruses that infect species of the genus Mycobacterium. Mycobacteriophages are categorized into clusters based primarily on nucleotide similarity (18). Some clusters are well-characterized, while others, such as Cluster E, are poorly characterized (20). There are 54 members of Cluster E (39) including the phage Ukulele that was isolated at the University of Maine in 2011. This thesis is aimed towards characterizing Cluster E phages using Ukulele as a model. Cluster E phages have long tails of approximately 300 nm and they produce slightly turbid plaques on a lawn of Mycobacterium smegmatis. Putative …