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Biochemistry, Biophysics, and Structural Biology

Syracuse University

2010

Articles 1 - 6 of 6

Full-Text Articles in Life Sciences

The Role Of Cuticular Hydrocarbons In The Pre-Mating Isolation Of Two Pissodes Species, Stephanie L. Teale May 2010

The Role Of Cuticular Hydrocarbons In The Pre-Mating Isolation Of Two Pissodes Species, Stephanie L. Teale

Honors Capstone Projects - All

Pissodes strobi and P. nemorensis are weevils (Coleoptera, Curculionidae) that infest pines (Pinus spp.) and spruces (Picea spp.). Previous studies indicate that they are able to hybridize. In the spring, breeding site specificity maintains reproductive isolation, but in the late summer, both species occupy lateral branches of host trees. Aggregation pheromones for P. nemorensis have been identified but the mechanism for late summer isolation is unknown. Cuticular hydrocarbons have been shown to play a role in the chemical recognition of species, sex, kin, and caste in many groups of insects. The large number of possible compounds and the …


Role Of Secondary Interactions (Π, Agostic) As Well As Solvent Influence On Alkali Metal Complexes, Elizabeth D. Nagle May 2010

Role Of Secondary Interactions (Π, Agostic) As Well As Solvent Influence On Alkali Metal Complexes, Elizabeth D. Nagle

Honors Capstone Projects - All

We here attempt to synthesize heterobimetallic alkali metal complexes with bulky phenolate ligands via solid state direct metallation. The solid state route may offer a facile method of producing these heterobimetallic species. Synthesis of heterobimetallic alkali metal compounds remains a challenge, as the homometallic complexes are generally favored over formation of the heterobimetallic species. Previous work has shown that the alkali metals have a strong solvent dependency; the recrystallization of heterobimetallic products from toluene yields the heterobimetallic, while recrystallization from THF yields the homometallic. However, the ability for phenolate ligands to stabilize metal centers through secondary interactions, such as M∙∙∙π …


Mtor In Cell Signaling And Size Enlargement As A Target For The Chemico-Physical Therapy Of Cancer, Gabriela Krawiec May 2010

Mtor In Cell Signaling And Size Enlargement As A Target For The Chemico-Physical Therapy Of Cancer, Gabriela Krawiec

Honors Capstone Projects - All

mTOR is a kinase protein meaning it phosphorylates target proteins affecting their cell signaling properties1. The drug Rapamycin, analogs of Rapamycin, and cell signaling proteins that interact with mTOR control the activities mediated by mTOR1. mTOR is located in the cytoplasm at a convergent point of many signaling pathways that regulate a multiplicity of cellular processes including metabolism that precede cell enlargement (cell “growth”), cell proliferation (cell division), and angiogenesis1,2. Cells with mTOR inappropriately activated can proceed with cell enlargement and cell proliferation in the absence of normal cell signaling2. Rapamycin and …


Understanding The Genetic And Molecular Mechanisms Of The Shl3 Phenotype In Arabidopsis Thaliana, Sukeerti Kesar May 2010

Understanding The Genetic And Molecular Mechanisms Of The Shl3 Phenotype In Arabidopsis Thaliana, Sukeerti Kesar

Honors Capstone Projects - All

The study of plant genetics and the molecular mechanisms regulating plant-pathogen interactions is an intensely studied area of research in molecular genetics. Gaining an understanding of the defense mechanisms of plants has proven highly useful in the construction of transgenic plants for increased crop yield. The focus of my research was on the defense mechanisms of Arabidopsis thaliana, a plant in the mustard family. Several features of Arabidopsis make it an excellent model plant for molecular genetic studies. A few of these include a short life cycle (approximately 8 weeks), a completely sequenced genome, high fecundity, and the availability …


The Effect Of Exogenous Estrogens On Primordial Follicle Assembly In Vivo, Jenna Rose Karavan May 2010

The Effect Of Exogenous Estrogens On Primordial Follicle Assembly In Vivo, Jenna Rose Karavan

Honors Capstone Projects - All

During embryogenesis in the mouse, primordial germ cells develop, move to the genital ridge of the embryo, and form germline cysts as the ovary develops. The cells in these cysts are linked by intercellular bridges. The cysts then undergo a breakdown process which ultimately results in primordial follicles, each of which consists of a single oocyte surrounded by somatic cells called granulosa cells. During this cyst breakdown process, approximately one-third of the original oocytes become enclosed in primordial follicles, the amount of which is representative of the number of eggs a female will have available to her during her reproductive …


Investigation Of Near-Infrared Fluorescence And Photobleaching Of Human Volar Side Fingertips In Vivo: Antioxidants And Melanin, Colin Wright May 2010

Investigation Of Near-Infrared Fluorescence And Photobleaching Of Human Volar Side Fingertips In Vivo: Antioxidants And Melanin, Colin Wright

Honors Capstone Projects - All

Noninvasive in vivo blood glucose determination in the skin of volar side of human fingertips by near-infrared (NIR) Raman spectroscopy relies on fluorescence to quantify blood volume. Fluorescence does not only come from blood, which is composed of plasma and red blood cells; in fact, most fluorescence produced by human fingertips originates in the static tissues, e.g. skin, interstitial fluid, etc.. It will soon be possible to quantify the precise contributions of red blood cells, plasma, and static tissue to the overall fluorescence emission. Observations reveal a systematic decay in fluorescence, which, if not caused by blood movement, challenges our …