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Evolution And Diversity Of Periplasmic Proteins Involved In Copper Homeostasis In Gamma Proteobacteria., José Argüello, Georgina Hernandez-Montes, Brenda Valderrama

José M. Argüello

Background: Different systems contributing to copper homeostasis in bacteria have been described in recent years involving periplasmic and transport proteins that provide resistance via metal efflux to the extracellular media (CopA/Cue, Cus, Cut, and Pco). The participation of these proteins in the assembly of membrane, periplasmic and secreted cuproproteins has also been postulated. The integration and interrelation of these systems and their apparent redundancies are less clear since they have been studied in alternative systems. Based on the idea that cellular copper is not free but rather it is transferred via protein-protein interactions, we hypothesized that systems would coevolve and …