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Full-Text Articles in Life Sciences
Preparation And Fungitoxicity Of 3-Bromo-6-Chloro- And 6-Bromo-3-Chloro-8-Quinolinols / Gershon H., Clarke D. D., Gerhson M, Department Of Chemistry, Fordham University, Bronx, Ny 10458, Usa, New York Botanical Garden, Bronx, Ny 10458, Usa, Herman Gershon, Donald Dudley Clarke Phd, Muriel Gershon
Preparation And Fungitoxicity Of 3-Bromo-6-Chloro- And 6-Bromo-3-Chloro-8-Quinolinols / Gershon H., Clarke D. D., Gerhson M, Department Of Chemistry, Fordham University, Bronx, Ny 10458, Usa, New York Botanical Garden, Bronx, Ny 10458, Usa, Herman Gershon, Donald Dudley Clarke Phd, Muriel Gershon
Chemistry Faculty Publications
3-Bromo-6-chloro- and 6-bromo-3-chloro-8-nitro, -8-amino-, and -8-hydroxyquinolines along with 3-bromo- and 3-chloroquinolin-6,8-diols were prepared and tested for antifungal activity against six fungi (Aspergillus niger, A. oryzae, Myrothecium verrucaria, Trichoderma viride, Mucor cirinelloides, Trichophyton mentagrophytes) in Sabouraud dextrose broth. Compounds with chlorine in the 3 position were generally more fungitoxic than the corresponding analogues with bromine. 6-Bromo-3-chloro-8-quinolinol inhibited four fungi at levels below 1 μg/ml and A. niger and M. cirinelloides at 2 μg/ml each