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Glycosylation Of Cyclooxygenase-2 (Cox-2) Influences The Migratory And Invasive Potential Of Cells, Fahad Algaly, Julia Hand, Mary B. Sevigny
Glycosylation Of Cyclooxygenase-2 (Cox-2) Influences The Migratory And Invasive Potential Of Cells, Fahad Algaly, Julia Hand, Mary B. Sevigny
Natural Sciences and Mathematics | Faculty Research Posters
Prostaglandins are bioactive lipids involved in many physiological functions such as maintenance of the cardiovascular, immune, renal, and central nervous systems. They also play a role in certain diseases like arthritis, cancer, and Alzheimer’s. Cyclooxygenase-2 (COX-2) is the enzyme that catalyzes the initial rate-limiting step in the pathway that converts arachidonic acid to prostaglandins. COX-2 exists as two glycoforms with the molecular weights of 72 and 74 kDa, the latter resulting from the addition of a high mannose chain to the Asn580 residue ~50% of the time. The over-expression of COX-2 is believed to be linked to cancer progression and …
Glycosylation Of Cyclooxygenase-2 (Cox-2) Influences The Migratory Potential Of Cos-1 Cells, Julia Hand, Renee Dominguez, Miguel Regidor, Mary B. Sevigny
Glycosylation Of Cyclooxygenase-2 (Cox-2) Influences The Migratory Potential Of Cos-1 Cells, Julia Hand, Renee Dominguez, Miguel Regidor, Mary B. Sevigny
Natural Sciences and Mathematics | Faculty Research Posters
A cancer cell’s most threatening property is its ability to metastasize or detach from the primary tumor and migrate to other locations in the body. Previous studies have shown that overexpression of the enzyme cyclooxygenase-2 (COX-2) can increase the metastatic potential of several cell types. COX-2 is the rate-limiting enzyme in the prostanoid biosynthesis pathway, converting arachidonic acid to prostaglandin H2, an important signaling molecule in the body. Glycosylation of COX-2 at the amino acid site Asn580 occurs about 50% of the time, and this results in two forms of the enzyme with molecular weights 72 and 74kDa. The purpose …