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Articles 1 - 8 of 8
Full-Text Articles in Life Sciences
Developing A Microfluidic Lab-On-A-Chip Device To Assess The Correlation Between The Ratio Of H And L Ferritin In Maternal Serum And Preterm Birth, Kaitlyn Brower, Adam Woolley
Developing A Microfluidic Lab-On-A-Chip Device To Assess The Correlation Between The Ratio Of H And L Ferritin In Maternal Serum And Preterm Birth, Kaitlyn Brower, Adam Woolley
Journal of Undergraduate Research
Preterm birth is the leading cause of death in children under the age of 51 and is defined by the Centers for Disease Control as birth before 37 weeks gestation.2 It is estimated that 15 million babies are born premature annually and that PTB kills nearly 1 million babies every year. Currently, accurate detection of PTB risk isn’t possible and extrauterine treatments and interventions are insufficient.
Targeting Superoxide Dismutase-¬1 In Cancer, Laura Oh, Josh Andersen
Targeting Superoxide Dismutase-¬1 In Cancer, Laura Oh, Josh Andersen
Journal of Undergraduate Research
SOD1 is overexpressed in many cancers such as lung adenocarcinoma, non- small-cell lung cancer, and 70% of primary breast cancers. Traditionally, SOD1 is known as an antioxidant in the human body, but only 1% of SOD1 expressed in cells is necessary to keep superoxide radicals below cytotoxic levels, suggesting that SOD1 may have undiscovered functions. One of the known trademarks of cancer is the Warburg Effect defined by up-regulated glycolysis and down- regulated respiration. It is thought that this unique mode of metabolism promotes cancer cell growth. A recent study demonstrated that SOD1 functions to repress respiration through the casein …
Learning Chemistry Through Experimentation, Kyle Long, Jennifer Nielson
Learning Chemistry Through Experimentation, Kyle Long, Jennifer Nielson
Journal of Undergraduate Research
For the past five years, Dr. Jennifer Nielson has conducted research in Kampala, Uganda, located in south-central Africa. I have been able to join her for two of the five years, including this past year for nearly three weeks in August. Our research focuses on teaching basic chemistry principle that are difficult to comprehend by using experiments that demonstrate the general concept of atomic structures and functions.
Solving The Structure Of The Raptor-Cct Complex, Grant Ludlam, Barry Willardson
Solving The Structure Of The Raptor-Cct Complex, Grant Ludlam, Barry Willardson
Journal of Undergraduate Research
The protein Raptor is an essential component of the mechanistic target of rapamycin (mTOR) cell signaling complex 1 (mTORC1) (1). The mTORC1 complex is a master regulator of cell growth, making it a high-priority target in cancer and inflammation research (2). Before Raptor can be assembled into the mTORC1, it is first folded by the chaperone protein cytosolic chaperonin containing TCP1 (CCT). CCT is composed of two rings of 8 different subunits, which together form a barrel shape. CCT substrates are folded in the 85 Å wide folding cavity inside the barrel.
Software Package For Mass Spectrometry Isotope Analysis And Extraction, Michael Porter, Dr. John Price
Software Package For Mass Spectrometry Isotope Analysis And Extraction, Michael Porter, Dr. John Price
Journal of Undergraduate Research
Proteins are involved in nearly every cellular process. They transport molecules, replicate DNA, catalyze reactions, respond to stimuli, and form the structural framework of the cell. The diversity of protein function has led to an interest in understanding the cellular production and control of individual proteins which in turn is key to understanding how the cell responds to the environment and what occurs on a molecular level during disease.
Microbial Pretreatment Of Waste For Anaerobic Digestion, Braden Myers, Jaron Hansen
Microbial Pretreatment Of Waste For Anaerobic Digestion, Braden Myers, Jaron Hansen
Journal of Undergraduate Research
The aim of this research was to demonstrate Caldicellulosiruptor bescii is a feasible microbial pretreatment of lignocellulose for enhanced production of biogas when coupled with secondary anaerobic digestion. Before anaerobic digestion of waste can reach its maximum energy production potential, economically sound methods for pretreatments that allow increased digestion of waste materials must be developed. Many types of waste cannot be broken down sufficiently by anaerobic digestion alone. Overcoming this hurdle through successful feedstock pretreatment would unlock a vast potential supply of renewable energy feedstock materials.
Understanding The Interaction Between Ulk1 And Atg9 And Autophagy, Ryan Hyatt, Joshua L. Andersen
Understanding The Interaction Between Ulk1 And Atg9 And Autophagy, Ryan Hyatt, Joshua L. Andersen
Journal of Undergraduate Research
Autophagy is an adaptive catabolic process of self-digestion, a process by which the cell recycles aged organelles and other structures. Interestingly, changes in the regulation of autophagy have been linked to infections, cancers, neurodegeneration, aging, and heart disease (Arroyo, Daniela S. et al. 2014). Understanding the mechanisms which control autophagy will aid in better treatment of those diseases, specifically in the development of effective pharmaceuticals.
The Mechanism Of Homogeneous Hg-Catalyzed Methane Partial Oxidation, Steven Butler, Daniel Ess
The Mechanism Of Homogeneous Hg-Catalyzed Methane Partial Oxidation, Steven Butler, Daniel Ess
Journal of Undergraduate Research
There is now access to vast amounts of inexpensive natural gas, due in part to shale gas discoveries. Abundant natural gas provides significant motivation to develop methods for methane partial oxidation. One major target for methane oxidation is methanol. Natural gas is principally methane, but also includes significant amounts of ethane and propane. Methanol can be produced from natural gas via high-temperature generation of syngas (mixture of H2 and CO).