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A Likelihood Ratio Test For Changes In Homeolog Expression Bias, Ronald D. Smith, Taliesin J. Kinser, Gregory D. Conradi Smith, Joshua R. Puzeyn
A Likelihood Ratio Test For Changes In Homeolog Expression Bias, Ronald D. Smith, Taliesin J. Kinser, Gregory D. Conradi Smith, Joshua R. Puzeyn
Arts & Sciences Articles
Background
Gene duplications are a major source of raw material for evolution and a likely contributor to the diversity of life on earth. Duplicate genes (i.e., homeologs, in the case of a whole genome duplication) may retain their ancestral function, sub- or neofunctionalize, or be lost entirely. A primary way that duplicate genes evolve new functions is by altering their expression patterns. Comparing the expression patterns of duplicate genes gives clues as to whether any of these evolutionary processes have occurred.
Results
We develop a likelihood ratio test for the analysis of the expression ratios of duplicate genes across two …