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Functional Domains Of The Fatty Acid Transport Proteins: Studies Using Protein Chimeras, Concetta C. Dirusso, Dina Darwis, Thomas Obermeyer, Paul N. Black

Department of Biochemistry: Faculty Publications

Fatty acid transport proteins (FATP) function in fatty acid trafficking pathways, several of which have been shown to participate in the transport of exogenous fatty acids into the cell. Members of this protein family also function as acyl CoA synthetases with specificity towards very long chain fatty acids or bile acids. These proteins have two identifying sequence motifs: The ATP/AMP motif, an approximately 100 amino acid segment required for ATP binding and common to members of the adenylate-forming super family of proteins, and the FATP/VLACS motif that consists of approximately 50 amino acid residues and is restricted to members of …