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Molybdoproteomes And Evolution Of Molybdenum Utilization, Yan Zhang, Vadim N. Gladyshev

Vadim Gladyshev Publications

The trace element molybdenum (Mo) is utilized in many life forms, where it is a key component of several enzymes involved in nitrogen, sulfur, and carbon metabolism. With the exception of nitrogenase, Mo is bound in proteins to a pterin, thus forming the molybdenum cofactor (Moco) at the catalytic sites of molybdoenzymes. Although a number of molybdoenzymes are well characterized structurally and functionally, evolutionary analyses of Mo utilization are limited. Here, we carried out comparative genomic and phylogenetic analyses to examine occurrence and evolution of Mo utilization in bacteria, archaea, and eukaryotes at the level of (i) Mo transport and …