Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
The Ligand-Binding Profile Of Hare: Hyaluronan And Chondroitin Sulfates A, C, And D Bind To Overlapping Sites Distinct From The Sites For Heparin, Acetylated Low-Density Lipoprotein, Dermatan Sulfate, And Cs-E, Ed Harris, Paul H. Weigel
The Ligand-Binding Profile Of Hare: Hyaluronan And Chondroitin Sulfates A, C, And D Bind To Overlapping Sites Distinct From The Sites For Heparin, Acetylated Low-Density Lipoprotein, Dermatan Sulfate, And Cs-E, Ed Harris, Paul H. Weigel
Department of Biochemistry: Faculty Publications
Abstract The hyaluronic acid receptor for endocytosis (HARE)/ Stabilin-2 is the primary systemic scavenger receptor for hyaluronan (HA), the chondroitin sulfates (CS), dermatan sulfate (DS), and nonglycosaminoglycan (GAG) ligands such as acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides, and advanced glycation end products. We recently discovered that HARE is also a systemic scavenger receptor for heparin (Hep) (Harris EN, Weigel JA, Weigel PH. 2008. The human hyaluronan receptor for endocytosis [HARE/Stabilin-2] is a systemic clearance receptor for heparin. J Biol Chem. 283:17341–17350). Our goal was to map the binding sites of eight different ligands within HARE. We used biotinylated GAGs and …