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Biochemistry, Biophysics, and Structural Biology

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University of Nebraska - Lincoln

Department of Biochemistry: Dissertations, Theses, and Student Research

2008

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Full-Text Articles in Life Sciences

Identification And Characterization Of A Cadmium-Transporting P-Type Atpase In Yeast Saccharomyces Cerevisiae, David J. Adle Dec 2008

Identification And Characterization Of A Cadmium-Transporting P-Type Atpase In Yeast Saccharomyces Cerevisiae, David J. Adle

Department of Biochemistry: Dissertations, Theses, and Student Research

Detoxification and homeostatic acquisition of metal ions are vital for all living organisms. Non-physiological heavy metals are toxic at low concentrations and represent major environmental hazards to human health. In particular, cadmium is a toxic environmental pollutant linked to a number of ailments including cancer, kidney and bone disease and reproductive disorders. The biological effects of cadmium toxicity which lead to human disease and the cellular mechanisms for cadmium defense are ill defined. Thus, the study of heavy metal detoxification systems represents an important research avenue to help combat cadmium related disorders.

The goal of this research project was to …