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Articles 1 - 5 of 5
Full-Text Articles in Life Sciences
A Seed Dormancy Gene-Mediated Biotechnology To Mitigate Transgene Flow Into Weedy Rice, Luai Nahar Muhammad
A Seed Dormancy Gene-Mediated Biotechnology To Mitigate Transgene Flow Into Weedy Rice, Luai Nahar Muhammad
Electronic Theses and Dissertations
Transgene flows into wild/weedy relatives may cause ecological and economic problems. Seed dormancy is an adaptive trait that distributes germination over time and promotes persistence of weeds in agroecosystems. Silencing natural genes controlling seed dormancy (SD) could promote germination and reduce weed adaptability. The goal of this project was to develop a transgenic mitigation (TM) technology by linking to a primary transgene with an SD gene-silencing structure, as a tandem construct for transformation, to reduce the risk of gene flow into weed populations. In this research, the Bar (Bialaphos) gene for resistance to the glufosinate herbicide was used as a …
Discovery And Characterization Of Novel Substrate Selective Inhibitors Of Human Mrp1 (Abcc1), Angelina Sampson
Discovery And Characterization Of Novel Substrate Selective Inhibitors Of Human Mrp1 (Abcc1), Angelina Sampson
Electronic Theses and Dissertations
Multidrug resistance protein 1 (MRP1/ABCC1) actively transports a variety of drugs, toxic molecules and important physiological substrates across the plasma membrane. It can confer broad-spectrum drug resistance and can decrease the bioavailability of many important drugs such as anti-cancer agents, antibiotics, antivirals, antidepressants and antiinflammatory drugs. Calcein-AM, a fluorescent reporter commonly used for studying compound interactions with MRP1 was recently used in the development of a high content imaging-based assay by our group. This assay was robust and had better sensitivity than fluorescent plate readouts. The assay identified 12 MRP1 inhibitors after screening an anticancer library of 386 compounds. Due …
Disease Resistance In Wheat And Its Relatives, Ethan James Andersen
Disease Resistance In Wheat And Its Relatives, Ethan James Andersen
Electronic Theses and Dissertations
Plants have evolved a complex defense system against pests and pathogens utilizing many types of receptors, signaling factors, and defense compounds to detect pathogen presence and respond effectively. Since many pathogens have evolved immunesuppressing effectors used to reduce plant resistance, plants have evolved a family of receptors that detect pathogenic effectors as a result of an evolutionary arms race. These receptors contain Nucleotide-Binding Site and Leucine-Rich Repeat domains and are called NBS-LRR or NLR proteins. Many grasses possess huge genomes with hundreds of NLR-encoding genes, often found in clusters at the extra-pericentromeric regions of chromosomes, where unequal crossing over causes …
Novel Hybrid Analogs Of Estrone Origin Exhibits Cytotoxic Effects Against Egfr-Dependent Cancers, Felix Acheampong
Novel Hybrid Analogs Of Estrone Origin Exhibits Cytotoxic Effects Against Egfr-Dependent Cancers, Felix Acheampong
Electronic Theses and Dissertations
Cancer is second only to cardiovascular illnesses as the deadliest human disease globally. Currently, non-small cell lung cancer (NSCLC) and triple negative breast carcinoma (TNBC) are the most frequent types of cancer and have the highest mortalities. Epidermal growth factor receptor (EGFR), a central regulator of tumor progression, is frequently overexpressed in both cancers and is a key clinical target for therapeutic intervention. Natural products and their synthetic analogs have been utilized as EGFR tyrosine kinase inhibitors (TKIs) with potent antitumor effects. However, acquired resistance limits the long-term efficacy of these drugs. Estrone has been used as a scaffold in …
Analysis Of The Molecular Mechanisms Governing Fcγ Receptor Activation On The Surfaces Of Macrophages By Advanced Optical Microscopy, Elizabeth Michelle Bailey
Analysis Of The Molecular Mechanisms Governing Fcγ Receptor Activation On The Surfaces Of Macrophages By Advanced Optical Microscopy, Elizabeth Michelle Bailey
Electronic Theses and Dissertations
Therapeutic antibodies are achieving new levels of therapeutic success in treating cancers and immunological disorders by antibody engagement of Fc receptor-directed immune responses. Conversely, inhibiting autoantibody induced Fc receptor activation is an attractive approach to treat autoimmune diseases. Immunoglobulin G (IgG) antibodies are often the principal subclass used in therapeutic antibodies and associated with autoimmune pathologies because of their long circulation and potent effector functions, including activation of the Fcγ Receptor (FcγR). Thus, a thorough understanding of the FcγR activation is required to improve the efficacy of immunotherapies and to mitigate autoimmunities. It is well established that FcγR clustering is …