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Articles 1 - 9 of 9
Full-Text Articles in Life Sciences
The European Eel Nccβ Gene Encodes A Thiazide-Resistant Na-Cl Cotransporter, Erika Moreno, Consuelo Plata, Alejandro Rodríguez-Gama, Eduardo R. Argaiz, Norma Vázquez, Karla Leyva, Carmen Y. Hernández-Carballo, León Islas, Christopher P. Cutler, Diana Pacheco-Alvarez, Adriana Mercado, Raquel Cariño-Cortés, Gerardo Gamba
The European Eel Nccβ Gene Encodes A Thiazide-Resistant Na-Cl Cotransporter, Erika Moreno, Consuelo Plata, Alejandro Rodríguez-Gama, Eduardo R. Argaiz, Norma Vázquez, Karla Leyva, Carmen Y. Hernández-Carballo, León Islas, Christopher P. Cutler, Diana Pacheco-Alvarez, Adriana Mercado, Raquel Cariño-Cortés, Gerardo Gamba
Department of Biology Faculty Publications
The thiazide-sensitive Na-Cl cotransporter (NCC) is the major pathway for salt reabsorption in the mammalian distal convoluted tubule. NCC plays a key role in the regulation of blood pressure. Its inhibition with thiazides constitutes the primary baseline therapy for arterial hypertension. However, the thiazide-binding site in NCC is unknown. Mammals have only one gene encoding for NCC. The eel, however, contains a duplicate gene. NCCα is an ortholog of mammalian NCC and is expressed in the kidney. NCCβ is present in the apical membrane of the rectum. Here we cloned and functionally characterized NCCβ from the European eel. The cRNA …
Population Viability Analysis For Endangered Roanoke Logperch, James Henry Roberts, Paul L. Angermeier, Gregory B. Anderson
Population Viability Analysis For Endangered Roanoke Logperch, James Henry Roberts, Paul L. Angermeier, Gregory B. Anderson
Department of Biology Faculty Publications
A common strategy for recovering endangered species is ensuring that populations exceed the minimum viable population size (MVP), a demographic benchmark that theoretically ensures low long-term extinction risk. One method of establishing MVP is population viability analysis, a modeling technique that simulates population trajectories and forecasts extinction risk based on a series of biological, environmental, and management assumptions. Such models also help identify key uncertainties that have a large influence on extinction risk. We used stochastic count-based simulation models to explore extinction risk, MVP, and the possible benefits of alternative management strategies in populations of Roanoke logperch Percina rex, an …
A Long-Term Study Of Ecological Impacts Of River Channelization On The Population Of An Endangered Fish: Lessons Learned For Assessment And Restoration, James Henry Roberts, Gregory B. Anderson, Paul L. Angermeier
A Long-Term Study Of Ecological Impacts Of River Channelization On The Population Of An Endangered Fish: Lessons Learned For Assessment And Restoration, James Henry Roberts, Gregory B. Anderson, Paul L. Angermeier
Department of Biology Faculty Publications
Projects to assess environmental impact or restoration success in rivers focus on project-specific questions but can also provide valuable insights for future projects. Both restoration actions and impact assessments can become “adaptive” by using the knowledge gained from long-term monitoring and analysis to revise the actions, monitoring, conceptual model, or interpretation of findings so that subsequent actions or assessments are better informed. Assessments of impact or restoration success are especially challenging when the indicators of interest are imperiled species and/or the impacts being addressed are complex. From 1997 to 2015, we worked closely with two federal agencies to monitor habitat …
Teaching For Higher Levels Of Thinking: Developing Quantitative And Analytical Skills In Environmental Science Courses, Adriana Bravo, Ana Porzecanski, Eleanor Sterling, Nora Bynum, J. Michelle Cawthorn, Denny S. Fernandez Del Viso, Laurie Freeman, Stuart Ketcham, Timothy Leslie, John Mull, Donna Vogler
Teaching For Higher Levels Of Thinking: Developing Quantitative And Analytical Skills In Environmental Science Courses, Adriana Bravo, Ana Porzecanski, Eleanor Sterling, Nora Bynum, J. Michelle Cawthorn, Denny S. Fernandez Del Viso, Laurie Freeman, Stuart Ketcham, Timothy Leslie, John Mull, Donna Vogler
Department of Biology Faculty Publications
Professionals with strong quantitative and analytical skills are essential to understanding and responding to current environmental challenges. The goal of this study was to promote and evaluate the development of data analysis (DA) skills in undergraduate students through targeted interventions in environmental science courses. We developed materials to promote practice, instruction, and assessment of four core DA dimensions: the ability to make appropriate calculations, convert data to graphical representations, interpret graphical or mathematical information, and draw conclusions based on the analysis of data. We integrated two conservation exercises as pre/post assessment tools, flanking differentiated teaching interventions, into selected science courses …
Synthesis And Characterization Of Nanoparticle-Coupled Proteins In Human Serum Albumin, Kyle M. Mahoney
Synthesis And Characterization Of Nanoparticle-Coupled Proteins In Human Serum Albumin, Kyle M. Mahoney
Honors College Theses
Recently, cancer has become an ever-growing issue and has led to many researchers attempt to unravel the mystery of the disease. This research has led to a promising field of treatment: nanotechnology-coupled pharmaceuticals. Nanoparticles act as a whole unit when in conjugation with other molecules and add to the carrier molecule, most often proteins, benefits the nanoparticles themselves possess. One such carrier protein that can be conjugated with nanoparticles is Human Serum Albumin (HSA). Albumin is of interest in cancer research for two reasons: it is native to the human vasculature so it does not elicit immunological reactions, and it …
Consequences Of Secondary Calibrations On Divergence Time Estimates, John J. Schenk
Consequences Of Secondary Calibrations On Divergence Time Estimates, John J. Schenk
Department of Biology Faculty Publications
Secondary calibrations (calibrations based on the results of previous molecular dating studies) are commonly applied in divergence time analyses in groups that lack fossil data; however, the consequences of applying secondary calibrations in a relaxed-clock approach are not fully understood. I tested whether applying the posterior estimate from a primary study as a prior distribution in a secondary study results in consistent age and uncertainty estimates. I compared age estimates from simulations with 100 randomly replicated secondary trees. On average, the 95% credible intervals of node ages for secondary estimates were significantly younger and narrower than primary estimates. The primary …
Small Molecule Disruption Of Ros-Regulating Pathways In Human Carcinoma, Rebecca E. Mccall
Small Molecule Disruption Of Ros-Regulating Pathways In Human Carcinoma, Rebecca E. Mccall
Electronic Theses and Dissertations
Gold (I) coordinated N-heterocyclic carbenes containing appended redox cycling moieties were designed and analyzed for their ability to target the antioxidant network via multiple mechanisms in various human cancer cell models. Complexes containing either ferrocene or naphthoquinone redox cycling moieties were screened for inhibition of cell growth, inhibition of thioredoxin reductase (TrxR), and accentuation of exogenous ROS. The cell death pathway employed was determined by flow cytometry via detection of Annexin-V FITC. Furthermore, differential gene expression between treated cells and untreated cells revealed the induction of endoplasmic reticulum stress and unfolded protein response pathways.
Carinata Fame Production Process And Biofuel Oxidation, Benoit Kindo
Carinata Fame Production Process And Biofuel Oxidation, Benoit Kindo
Honors College Theses
In this experiment, the contribution of a standard production method for biofuels on their oxidative stability was investigated. Peroxide values were measured at different steps of the production process of Brassica carinata and peanut-based biofuels. The washing and drying steps in this production method showed significant increases in peroxide values for both biofuels and was identified as a major contributor of biofuel oxidation. Further analyses of the physical and thermal properties showed a more pronounced affect in the biofuel from Bassica carinata, and indicated an unusual composition much higher in saturated fatty acids much longer than those found in peanut. …
Epigenetic Response To Habitat Change: Changes Variation In Dna Methylation Frequencies And Generational Transmission Vary With Invasion Status, Aaron W. Schrey, Travis R. Robbins, Jacob D. Lee, David W. Dukes, Alexandria K. Ragsdale, Christopher J. Thawley, Tracy Langkilde
Epigenetic Response To Habitat Change: Changes Variation In Dna Methylation Frequencies And Generational Transmission Vary With Invasion Status, Aaron W. Schrey, Travis R. Robbins, Jacob D. Lee, David W. Dukes, Alexandria K. Ragsdale, Christopher J. Thawley, Tracy Langkilde
Department of Biology Faculty Publications
Epigenetic mechanisms may be important for a native species’ response to rapid environmental change. Red Imported Fire Ants (Solenopsis invicta Santschi, 1916) were recently introduced to areas occupied by the Eastern Fence Lizard (Sceloporus undulatus Bosc & Daudin, 1801). Behavioral, morphological and physiological phenotypes of the Eastern Fence Lizard have changed following invasion, creating a natural biological system to investigate environmentally induced epigenetic changes. We tested for variation in DNA methylation patterns in Eastern Fence Lizard populations associated with different histories of invasion by Red Imported Fire Ants. At methylation sensitive amplified fragment length polymorphism loci, we detected a higher …