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Full-Text Articles in Life Sciences
Protection Against Atherosclerosis By A Non-Native Pentameric Crp That Shares Its Ligand Recognition Functions With An Evolutionarily Distant Crp, Asmita Pathak
Electronic Theses and Dissertations
C-reactive protein (CRP) is an acute phase protein of the innate immune system that has been evolutionarily conserved. Human CRP is known to exist in two different pentameric conformations; native CRP and non-native CRP that possess differential ligand recognition functions. The structure of CRP evolved from arthropods to humans, in terms of subunit composition, disulfide bonds, and glycosylation pattern. Along with change in structure, the gene expression pattern of CRP also evolved from a constitutive protein in lower invertebrates to an acute phase protein in humans. The objective of this study was to determine the function of a non-native pentameric …
The Effects Of Framework Mutations At The Variable Domain Interface On Antibody Affinity Maturation In An Hiv-1 Broadly Neutralizing Antibody Lineage, Jeffrey O. Zhou , '19, Hussain A. Zaidi , '22, Therese Ton , '19, Daniela Fera
The Effects Of Framework Mutations At The Variable Domain Interface On Antibody Affinity Maturation In An Hiv-1 Broadly Neutralizing Antibody Lineage, Jeffrey O. Zhou , '19, Hussain A. Zaidi , '22, Therese Ton , '19, Daniela Fera
Chemistry & Biochemistry Faculty Works
Understanding affinity maturation of antibodies that can target many variants of HIV-1 is important for vaccine development. While the antigen-binding site of antibodies is known to mutate throughout the co-evolution of antibodies and viruses in infected individuals, the roles of the mutations in the antibody framework region are not well understood. Throughout affinity maturation, the CH103 broadly neutralizing antibody lineage, from an individual designated CH505, altered the orientation of one of its antibody variable domains. The change in orientation was a response to insertions in the variable loop 5 (V5) of the HIV envelope. In this study, we generated CH103 …
Consciousness As A Factor In Evolution, Kenneth A. Augustyn
Consciousness As A Factor In Evolution, Kenneth A. Augustyn
Michigan Tech Publications
What I call the mind began as a non-conscious robotic biochemical process control system in the very earliest forms of life. As life evolved, problems in control became more difficult and exceeded the computational capabilities of the organisms. Nature discovered a means of transcending computable physical processes resulting in non-computational subjective mental capabilities that, while still not conscious, had a degree of genuine autonomy from the physical world. These autonomous subjective wants and goals now affected the course of (but not the mechanism of) evolution. The integrated amalgam of robotic and transrobotic unconscious capabilities eventually gave rise to consciousness, which …