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Full-Text Articles in Life Sciences
Probing Large Intrinsically Disordered Regions Through Novel Sortase-Mediated Ligation, Leah Kjormoe
Probing Large Intrinsically Disordered Regions Through Novel Sortase-Mediated Ligation, Leah Kjormoe
Scholars Week
In the realm of proteins, it is widely accepted that structure informs function. However, there are many proteins that contain intrinsically disordered regions (IDRs). These regions are areas in which the protein lacks defined structure, and IDPs are also often unstable, which complicates structural studies. NMR spectroscopy is an established method for probing protein structure and has been applied to that end in small IDRs. However, larger IDRs often have spectral overlap that makes data difficult to interpret. Furthermore, low-concentration samples limit spectral clarity. One method to address these difficulties is to use sortase ligation and segmental labeling, which increases …
295— Biomimicry: Investigating The Active Site Model Of Lactate Racemase, Stephanie Podguski, Maisy Ross
295— Biomimicry: Investigating The Active Site Model Of Lactate Racemase, Stephanie Podguski, Maisy Ross
GREAT Day Posters
Because of humans’ heavy impact on nature with industrialization and resource extraction, biomimetics, also known as biomimicry, is a study that has emerged. Biomimetics utilizes observations from nature to comprehend the principles of underlying mechanisms and apply concepts that may benefit science, medicine, engineering and the like. An area of biochemistry we are applying this to is the lactate racemase enzyme.This metalloenzyme is found in many prokaryotic organisms and catalyzes the interconversion between the two optical isomers of lactic acid. The structure of this enzyme consists of a square-planar nickel (II) ion coordinated by a histidine residue and a pincer …
206— Binding Of Telomeric Dna G-Quadruplexes By Abietane Diterpene Natural Products, Tarryn Franciosa, Sarah Ostrowski
206— Binding Of Telomeric Dna G-Quadruplexes By Abietane Diterpene Natural Products, Tarryn Franciosa, Sarah Ostrowski
GREAT Day Posters
G-quadruplexes are non-canonical higher order DNA structures formed from guanine rich sequences, made up of stacked G-tetrads stabilized by Hoogsteen base pairing and K+ ions. G-quadruplexes are overrepresented in the promoter regions of oncogenes and the 5’UTR of mRNA1. As a result, G-Quadruplexes have been implicated as targets for possible anti-cancer therapeutic agents to treat previously “undruggable” targets like the c-myc and ras oncogenes1. The human telomeric repeat, [5’G3(T2AG3)3], is a repeating, single stranded DNA sequence that can form G-quadruplexes. Telomerase, an enzyme expressed in ~90% of all cancers, is responsible for extending telomeric repeats, making cancer cells immortal. It …
385— Optimizing Nitrogen Concentrations To Maximize Lipid Yields For Biodiesel Production, Wady Jacoby, Daria Zhogina, Pavel Ananev, Lauren Saggese, Max Muller, Barnabas Gikonyo
385— Optimizing Nitrogen Concentrations To Maximize Lipid Yields For Biodiesel Production, Wady Jacoby, Daria Zhogina, Pavel Ananev, Lauren Saggese, Max Muller, Barnabas Gikonyo
GREAT Day Posters
Select subspecies of microalgae are considered to be the most promising candidates for third generation renewable resources of biodiesel. Algae not only ingest excess carbon emissions from the atmosphere, they also convert it into energy-dense lipids which can be harvested, and then transformed into biodiesel. However, before the fuel industry can adopt algae farming as a realistic alternative to fossil fuels, the process of harvesting algal lipids must be optimized further. Our research aims to make algal lipid extraction more realistic by determining the ideal growing conditions of the algae species Chlorella Vulgaris. Our research this semester focused on two …
Chem 490: Characterization Of Cellular Targets And Derivatization Of A Lipogenic Pt Anticancer Therapeutic, Keira D. Naff, Jonathan D. White
Chem 490: Characterization Of Cellular Targets And Derivatization Of A Lipogenic Pt Anticancer Therapeutic, Keira D. Naff, Jonathan D. White
2020 Virtual Spring Student Showcase for Research and Creative Inquiry
Platinum-based compounds have been a centerpiece of anticancer chemotherapies since the 1970s. Despite their widespread use, a seemingly endless challenge with these drugs is their toxicity, stemming from non-specific binding of Pt to cellular targets in healthy cells. Within the last few decades only a small number of new platinum-based drugs have demonstrated improved efficacy in any clinical trials, and none have received regulatory approval in the USA. Most of these efforts have focused on either developing improved methods of drug delivery, or on developing non-classical Pt complexes with alternative binding modes. We have begun to explore tethering Pt compounds …
Optimization Of Dapoxyl Aptamer For Label-Free Bioanalysis, Jack E. Mordeson, Ryan P. Connelly, Pedro F. Madalozzo, Yulia Gerasimova
Optimization Of Dapoxyl Aptamer For Label-Free Bioanalysis, Jack E. Mordeson, Ryan P. Connelly, Pedro F. Madalozzo, Yulia Gerasimova
Digital Repository: Showcase of Undergraduate Research Excellence
No abstract provided.