Life Sciences Commons^™

From Regulation Of Secondary Metabolites To Increased Virulence Under Sublethal Dosage Of Antibiotics: An Unprecedented Role Of Global Regulator, Mftr, In Burkholderia Thailandensis, Sudarshan Singh Thapa

LSU Doctoral Dissertations

The rise of multi-drug resistant bacteria combined with a decreasing pool of effective antibiotics has placed an increasing need for the development of novel antibiotics. Bacterial natural products or secondary metabolites have been the greatest source for development of novel antibiotics. The genus Burkholderia has recently emerged as a source of promising compounds with antibacterial, antifungal, and anti-cancer activities. Bacterial secondary metabolites provide added advantage to bacteria under stressful environments such as during host infection, evading predators or nutrient deficient conditions. However, genes involved in synthesis of these novel compounds remain silent under normal laboratory growth, creating a hurdle in …