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Structure Function Relationship In Hexacoordinate Heme Proteins: Mechanism Of Globin X Interactions With Exogenous Ligands And Ligand Accessiblity In Cytoglobin And Neuroglobin, Ruipeng Lei
FIU Electronic Theses and Dissertations
Cytoglobin (Cygb), neuroglobin (Ngb), and globin X (GbX) belongs to recently discovered members of the vertebrate globin family, they carry a heme prosthetic group that can reversibly bind exogenous ligands such as CO, NO and O2. Although the physiological functions of Cygb, Ngb and GbX are still under debate, several possible physiological functions for these proteins were proposed. Cytoglobin was reported to participate in lipid-based signaling and to stabilize the tumor suppressor p53 upon DNA damage, which imply its anti-cancer role. Neuroglobin was shown to interact with α-subunit of the heterotrimeric G protein as well as cytochrome c …