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A Novel Exo-Proteomic Approach To The Study Of Traumatic Brain Injury, Ron B. Moyron
A Novel Exo-Proteomic Approach To The Study Of Traumatic Brain Injury, Ron B. Moyron
Loma Linda University Electronic Theses, Dissertations & Projects
Concussions and Traumatic Brain Injuries (TBI) are significant health concerns and affect a wide cross section of society. Current diagnostic criteria and modalities, such as brain imaging and subjective measures of consciousness such as the Glasgow Coma Scale (GCS) score, are insufficient to properly diagnose the full spectrum of head injuries. Assessment of injury severity and outcome are further complicated by the vast array of symptoms, many of which mimic those displayed by other disorders. It is important to possess a better diagnostic tool for head injury triage and outcome prediction. One current line of inquiry seeks to discover a …
Rna-Seq Reveals Transcriptomic Program Associated With Stemness In Taxane Resistant Prostate Cancer, Christina K. Cajigas-Du Ross
Rna-Seq Reveals Transcriptomic Program Associated With Stemness In Taxane Resistant Prostate Cancer, Christina K. Cajigas-Du Ross
Loma Linda University Electronic Theses, Dissertations & Projects
There is no cure for advanced prostate cancer (PCa), and taxane chemotherapy is the only treatment option once other therapies have failed. However, this is problematic since all patients eventually develop chemoresistance. Emerging treatments for advanced PCa have shown promise at the benchside, but clinical trials have not resulted in newly approved drugs due in part to redundant survival pathways utilized by prostate tumor cells to maintain therapy-resistance. Using RNAsequencing—an innovative approach for quantifying gene expression changes—this dissertation sought to elucidate chemoresistance-associated molecular pathways as a catalyst to develop new therapeutic targets. Results revealed a differential upregulation of stemness-associated genes …
Aryl Hydrocarbon Receptor Mediated Restoration Of Cytoglobin As A Treatment For Breast Cancer, Leah Kathleen Rowland
Aryl Hydrocarbon Receptor Mediated Restoration Of Cytoglobin As A Treatment For Breast Cancer, Leah Kathleen Rowland
Loma Linda University Electronic Theses, Dissertations & Projects
Nearly 40,000 women die annually from breast cancer in the US. Clinically available targeted breast cancer therapy is ineffective in triple negative breast cancer (TNBC) subtypes, which lack expression of the estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2. TNBC carries a poor prognosis. Previous reports show that aryl hydrocarbon receptor (AhR) agonist 2-(4-amino-3-methylphenyl)- 5-fluorobenzothiazole (5F 203) selectively inhibits the growth of breast cancer cells including those of the TNBC subtype. In the current study, we determined that 5F 203 induces the expression of epigenetically silenced putative tumor suppressor gene cytoglobin (CYGB) and suppresses TNBC cell growth …
Pain And Stress In The Premature Infant, John Bryle Chong Tan
Pain And Stress In The Premature Infant, John Bryle Chong Tan
Loma Linda University Electronic Theses, Dissertations & Projects
Procedural pain and stress in premature neonates is currently assessed utilizing tools that lack objectivity and accuracy. This results in untreated or mismanaged pain. My dissertation utilized physiological methods and biochemical markers that identified pain in premature neonates and its effect on energy metabolism. The painful procedure that I examined is the retinopathy of premature (ROP) examination, a necessary and routine eye examination in the neonatal intensive care unit (NICU) that detects and identifies infants at risk for blindness due to retinal detachment. The effects of the ROP exam on peripheral and deep tissue oxyhemoglobin saturation and urinary purine degradation …