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Inhibition Of Rad52-Based Dna Repair For Cancer Therapy, Mona Al-Mugotir
Inhibition Of Rad52-Based Dna Repair For Cancer Therapy, Mona Al-Mugotir
Theses & Dissertations
Germline BRCA mutations underlay a significant risk for breast and ovarian cancer that increases in age. BRCA mutations are usually associated with the most aggressive subtypes of these cancers such as triple negative breast cancer and high-grade serous ovarian cancer. Conventional chemotherapeutic or hormonal therapies do not address the molecular deficiencies responsible for their resistance and there is a high rate of recurrence. Targeted therapy that can address the unique molecular features in these subtypes of cancer is the only way to cure the disease or, at the very least, improve patients’ quality of life.
Homologous recombination repair is an …