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A Study Of 5-Fluorouracil: Its Effects And Mode Of Action In Drosophila Melanogaster, John B. Jenkins Jr.
A Study Of 5-Fluorouracil: Its Effects And Mode Of Action In Drosophila Melanogaster, John B. Jenkins Jr.
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Investigations involving the fluorinated pyrimidine, 5-fluorouracil, and its effects on viruses, bacteria, plants and mammals, have brought to light the following facts: FU inhibits the growth of bacteria, plants and mammalian cells and it decreases the ability of certain viruses to produce progeny. In other words, FU is an antimetabolite that inhibits growth and/or reproduction. Two mechanisms have emerged from these studies to define the mode of action of FU. The first mechanism involves the incorporation of the compound into the RNA of the organism thus altering the base sequence and creating a non functional or damaging nucleic acid. The …