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Pop2: A Potential Regulator Of Hmt1-Catalyzed Arginine Methylation In Yeast, Celeste Excell
Pop2: A Potential Regulator Of Hmt1-Catalyzed Arginine Methylation In Yeast, Celeste Excell
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Protein arginine methylation is an important post-translational modification that is vital in regulating various cellular processes such as gene transcription, cell signaling, and RNA processing. Protein arginine methyltransferases (PRMTs) are responsible for performing this important modification. PRMT1 (protein arginine methyltransferase 1) and Hmt1 (hnRNP methyltransferase 1) are the predominant PRMTs in humans and yeast, respectively. Despite growing momentum in this field, relatively little is understood about PRMT regulation. Further work discovering how PRMTs are regulated will greatly advance our understanding of diseases where PRMTs have been implicated, such as heart disease, viral pathogenesis, and cancer.
It has been discovered that …