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Full-Text Articles in Life Sciences
Synthesis And Structure-Activity Relationship Study Of Novel Nitrodiphenylurea Antibiotics, Helen Bahlbi
Synthesis And Structure-Activity Relationship Study Of Novel Nitrodiphenylurea Antibiotics, Helen Bahlbi
Student Scholars Day Posters
According to the World Health Organization, tuberculosis (TB) is the leading cause of death by infectious disease. Tuberculosis is caused by the bacteria Mycobacterium tuberculosis and occurs globally. Additionally, in 2017, TB was reported in all 50 states. Due to the scope of TB, strict observation of patients is required to ensure adherence to the current drug regimen. However, most reported cases are in developing countries where proper care is difficult. With the emergence of multidrug-resistant TB exhibiting resistance to current treatments, novel antibiotics are needed. Recently, our lab discovered a family of diphenyl ureas that exhibit antimicrobial activity against …
Synthesis And Characterization Of Potential Pharmaceutical Analogs Of A Gvsu Lead Compound: An Investigation Of Antibiotic & Anti-Tumor Activity, Nicole Horne
Student Scholars Day Posters
In support of ongoing anti-microbial & anti-tumor research, analogs of a GVSU lead compound, a derivative of the known telomerase inhibitor BIBR1532, were synthesized. These compounds were submitted for biological analysis to determine pharmacological activity toward the discovery of either an antibiotic that can resist bacterial enzymatic degradation or a chemotherapeutic molecule that can destroy tumor cells without increasing toxicity. The anti-microbial interest in these compounds was based on the fact that they are non-penicillin based antibiotics and display a broad range of efficacy against targeted bacteria, including C. diff & MRSA, with minimal toxicity. These compounds were made via …
The Organic Synthesis Of Anthranilic Acid Derivatives As Potential Active Antibiotics, Paul Chappell
The Organic Synthesis Of Anthranilic Acid Derivatives As Potential Active Antibiotics, Paul Chappell
Student Scholars Day Posters
The objective of this research project was to synthesize multiple derivatives of anthranilic acid. These derivatives will then be tested for antibiotic activity against Staphylococcus aureus and Escherichia coli (E. coli). As bacteria become more resistant to penicillin-based antibiotics, the exploration of anthranilic acid-based antibiotics could serve an important role for future medical use. This research project included data collection via 1H-NMR, 12C-NMR, TLC, MP, and IR to determine purity for biological testing.