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Assessment Of Ovarian Reserve: Anti-Mullerian Hormone Versus Follicle Stimulating Hormone, Zehra Jamil, Syeda Sadia Fatima, Zahra Cheema, Safia Baig, Roha Ahmed Choudhary
Assessment Of Ovarian Reserve: Anti-Mullerian Hormone Versus Follicle Stimulating Hormone, Zehra Jamil, Syeda Sadia Fatima, Zahra Cheema, Safia Baig, Roha Ahmed Choudhary
Department of Biological & Biomedical Sciences
Background: This study aimed to evaluate the strength of anti-Mullerian hormone (AMH) and follicle stimulating hormone (FSH) in reflecting the antral follicle count (AFC) in infertile females.
Materials and methods: This cross-sectional study was conducted on 160 females, visiting infertility clinic for assisted reproduction. Serum samples collected on the 3rd day of the cycle were assayed for FSH, luteinizing hormone, and AMH while AFC was assessed via transvaginal ultrasound. The study cohort was segregated into three groups based on AFC.
Results: Chronological age and FSH was significantly high in females with very low AFC (P < 0.01 and 0.009, respectively), yet they failed to discriminate patients with normal and higher follicle count (P = 0.65 and 0.84). Conversely, AMH reported highly significant difference between very low AFC and with those having either normal AFC (P = 0.002) or higher AFC (P = 0.001). Moreover, a significant difference in AMH was observed between normal and higher AFC group (P = 0.04).
Conclusion: Compared to female's age …
Anti Mullerian Hormone: Ovarian Response Indicator In Young Patients Receiving Long Gnrh Agonist Protocol For Ovarian Stimulation, Zehra Jamil, Syeda Sadia Fatima, Rehana Rehman, Faiza Alam, Sara Arif
Anti Mullerian Hormone: Ovarian Response Indicator In Young Patients Receiving Long Gnrh Agonist Protocol For Ovarian Stimulation, Zehra Jamil, Syeda Sadia Fatima, Rehana Rehman, Faiza Alam, Sara Arif
Department of Biological & Biomedical Sciences
Objective: Anti Mullerian hormone (AMH) is gaining place as ovarian marker, chiefly in infertility assistance. We explored its correlation with oocytes retrieval after long GnRH agonist protocol for stimulation, in younger and older infertile population.
Methods: This retrospective analysis compiled data of 166 females, receiving ICSI treatment from June 2014 to March 2015. Serum FSH, LH, Estadiol, AMH and antral follicle count were assessed. Outcomes were measured as good (5 to 19 oocytes) and bad responders.
Results: Higher discriminatory power of AMH (AUROC; 0.771; p < 0.05) was seen in comparison to FSH (0.692; p < 0.05) and AFC (0.690; p < 0.01). AMH reported strongest association with oocyte retrieved (odds ratio of 15.06). Subgroup analysis reported 68.6 % risk of bad response with AMH levels of less than 1.37ng/ml. This association was observed more significant in young infertile patients <35 year of age (r=0.245; p=0.012) versus older population >35 year (r=0.169; p>0.05).
Conclusion: Our study reaffirms that serum AMH correlates well with …