Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Life Sciences
Treating Cancer With Heat: Hyperthermia As Promising Strategy To Enhance Apoptosis, Kanwal Ahmed, Syed Faisal Zaidi
Treating Cancer With Heat: Hyperthermia As Promising Strategy To Enhance Apoptosis, Kanwal Ahmed, Syed Faisal Zaidi
Department of Biological & Biomedical Sciences
The fundamental idea and the effects of heat on cancer cells are well known. However, the results obtained in therapy by hyperthermia (HT) alone have been only partially satisfactory. Treatment at temperatures between .40 and 44 degrees C is cytotoxic for cells in an environment with a low oxygen partial pressure and low pH, conditions that are found specifically within tumour tissue, due to insufficient blood perfusion. Under such conditions radiotherapy is less effective, and systemically applied cytotoxic agents will reach such areas in lower concentrations than in well-perfused areas. Therefore, clinically, it is preferred to use hyperthermia in combination …
Serene Threonine Kinase 39 Gene Single Nucleotide A-G Polymorphism Rs35929607 Is Weakly Associated With Essential Hypertension In Population Of Tharparkar, Pakistan, Loung Vasandas Umedani, Bushra Chaudhry, Vikram Mehraj, Muhammad Ishaq
Serene Threonine Kinase 39 Gene Single Nucleotide A-G Polymorphism Rs35929607 Is Weakly Associated With Essential Hypertension In Population Of Tharparkar, Pakistan, Loung Vasandas Umedani, Bushra Chaudhry, Vikram Mehraj, Muhammad Ishaq
Department of Biological & Biomedical Sciences
Objective: To study the prevalence of Serine Threonine Kinase-39 A-G polymorphism rs3592960 in rural population.
Methods: The random, cross-sectional study was carried out from 2009 to 2010 on 528 subjects in Tharparkar, Pakistan. Data was recorded excluding cases of secondary hypertension. Normotensives were used as the controls and hypertensives as the cases. Genotyping was carried out by tetra-primer amplification refraction mutation system-polymerase chain reaction method and the data was analysed statistically with SPSS-14.
Results: The association of Serine Threonine Kinase-39 rs35929607 with essential hypertension was as 3.07 (95% confidence interval 2.10-4.49) units/mmHg per G allele (p = 0.001). Raised systolic …
Acanthamoeba Castellanii Of The T4 Genotype Is A Potential Environmental Host For Enterobacter Aerogenes And Aeromonas Hydrophila, Farzana Abubakar Yousuf, Ruqaiyyah Siddiqui, Naveed Ahmed Khan
Acanthamoeba Castellanii Of The T4 Genotype Is A Potential Environmental Host For Enterobacter Aerogenes And Aeromonas Hydrophila, Farzana Abubakar Yousuf, Ruqaiyyah Siddiqui, Naveed Ahmed Khan
Department of Biological & Biomedical Sciences
Background: Acanthamoeba can interact with a wide range of microorganisms such as viruses, algae, yeasts, protists and bacteria including Legionella pneumophila, Pseudomonas aeruginosa, Vibrio cholerae, Helicobacter pylori, Listeria monocytogenes, Mycobacterium spp., and Escherichia coli. In this capacity, Acanthamoeba has been suggested as a vector in the transmission of bacterial pathogens to the susceptible hosts.
Methods: Here, we used a keratitis isolate of A. castellanii of the T4 genotype and studied its interactions with two bacterial genera which have not been tested before, Enterobacter aerogenes, and Aeromonas hydrophila, as well as E. coli. Assays were performed to determine bacterial association with …