Life Sciences Commons^™

Chem 490: Characterization Of Cellular Targets And Derivatization Of A Lipogenic Pt Anticancer Therapeutic, Keira D. Naff, Jonathan D. White

2020 Virtual Spring Student Showcase for Research and Creative Inquiry

Platinum-based compounds have been a centerpiece of anticancer chemotherapies since the 1970s. Despite their widespread use, a seemingly endless challenge with these drugs is their toxicity, stemming from non-specific binding of Pt to cellular targets in healthy cells. Within the last few decades only a small number of new platinum-based drugs have demonstrated improved efficacy in any clinical trials, and none have received regulatory approval in the USA. Most of these efforts have focused on either developing improved methods of drug delivery, or on developing non-classical Pt complexes with alternative binding modes. We have begun to explore tethering Pt compounds …