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To Establish Accurate Local Adult Reference Ranges For Routine Chemistries In A Large Diagnostic Clinical Biochemistry Laboratory In The Hse South Area, Barbara Kenneally

Theses

The objectives of this project were:

i. To establish adult reference ranges for routine chemistries quoted in the Clinical Biochemistry Department, Cork University Hospital (CUH), by using samples from blood donors at the local blood bank. 120 samples of blood from male blood donors and 120 samples from female blood donors were collected from the Irish Blood Transfusion Service (Cork). These samples were analysed for 21 routine chemistry analytes, using non-parametric statistics.

ii. To study the statistics of nineteen routine chemistries of the adult population served by the laboratory over a one- month period. Results were collected for each of …

Development Of An Immunoturbidimetric Particle Enhanced Assay For Detection Of C-Reactive Protein, Maria Nicholas

Theses

Background: C-reactive protein (CRP) is a well-known marker for inflammation. Recent studies have demonstrated that increases in CRP concentrations are associated with future coronary events in apparently healthy men and women. The requirement for assays, capable of testing CRP concentrations within the range 1-lOmg/l, is therefore great.

Methods: Two CRP assays were developed. The Sensitive assay is capable of measuring CRP concentrations as low as lmg/l for use as a potential cardiac marker test. The Normal assay can measure concentrations from 5-400mg/l for establishing levels of inflammation. Both assays developed are latex particle enhanced immunoturbidimetric assays designed for use on …