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Full-Text Articles in Life Sciences
A Fisher Indole Synthesis Approach To Phidianidine Analogues, Anna Tingler, Trinity Ghering, Samuel Ross
A Fisher Indole Synthesis Approach To Phidianidine Analogues, Anna Tingler, Trinity Ghering, Samuel Ross
Undergraduate Research Competition
Naturally occurring products are molecules that are found in the natural world without the aid of humans. Aspirin and opium are famous examples of this classification of molecule. Another example of natural products that are less known are the phidianidines. Phidianidines A & B were isolated from a shell-less mollusk, Phidiana militaris. These molecules are comprised of a 1,2,4-oxadiazole ring, an indole and an aminoalkylguanadio group. These compounds have exhibited striking pharmacological behavior such as that of neutralizing reactive oxygen species and acting as an agonist for the μ-opioid receptor. In recent years, the synthesis of phidianidine analogues has replaced …
A New Approach To The Core Of Flinderole C, Ana Pettijohn, Claire Romain
A New Approach To The Core Of Flinderole C, Ana Pettijohn, Claire Romain
Undergraduate Research Competition
The flinderoles A-C are a class of anti-malaria bisindole alkaloids from plants of the Flindersia genus. Flinderole C was specifically from the Papua New Guinean plant called F. amboinensis and is the most potent antimalarial of the group. Malaria is a parasitic infectious disease usually found in the hot, tropic regions of the world, such as parts of Africa. It is estimated that nearly half the world's population lives in an area where it is endemic. Furthermore, malaria was estimated to have caused over 600,000 deaths in 2020. While measures to limit the spread of the disease lessen its impact, …
Environmental Bacteriophage Presence In The Drainage Ponds At Coastal Carolina University, Alexei Chesnutwood
Environmental Bacteriophage Presence In The Drainage Ponds At Coastal Carolina University, Alexei Chesnutwood
Undergraduate Research Competition
The purpose of this research is to detect naturally occurring, lytic bacteriophages and identify the environmental factors that influence their presence on Coastal Carolina University’s campus. Bacteriophages are non-living viruses that only infect bacteria, and these viruses are found in abundance in every environment. Likewise, coliphages are viruses that exclusively infect coliform bacteria. Eleven treated and untreated freshwater sample sites were chosen for weekly sampling on CCU’s campus. During water sample collection, ambient environmental conditions were measured. In addition, precipitation was tracked over the collection period as runoff relates to the proliferation of bacteriophages. If plaque assays indicated the presence …
Developing A Safe And Effective Papillomavirus Screen To Be Used On College Students, Nicole Frantz
Developing A Safe And Effective Papillomavirus Screen To Be Used On College Students, Nicole Frantz
Undergraduate Research Competition
Human papillomavirus (HPV) is the most common sexually transmitted infection that accounts for approximately 5% of all cancers worldwide and affects more than 80 million people in the US alone, according to the CDC and National Cancer Institute. Human papillomaviruses are small, nonenveloped, icosahedral DNA viruses that infect squamous epithelial cells. The viral particles consist of a single double stranded DNA molecule bound to histones and contained within a protein capsid composed of structural proteins late (L)1 and L2. To date, over 100 different genotypes of HPV have been identified, and approximately 15 types are considered oncogenic in cervical, vulvar, …