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Full-Text Articles in Life Sciences
Severe Bone Marrow Suppression In A Patient With Rheumatoid Arthritis On Methotrexate, M P. Iqbal, A A. Ali, A A. Alvi
Severe Bone Marrow Suppression In A Patient With Rheumatoid Arthritis On Methotrexate, M P. Iqbal, A A. Ali, A A. Alvi
Department of Biological & Biomedical Sciences
No abstract provided.
Appearance Of A Methotrexate Binding Plasma Protein During High Dose Methotrexate Therapy, M P. Iqbal, I Malik, N Mehboobali
Appearance Of A Methotrexate Binding Plasma Protein During High Dose Methotrexate Therapy, M P. Iqbal, I Malik, N Mehboobali
Department of Biological & Biomedical Sciences
No abstract provided.
Methotrexate As An Alternative To Surgery In Ectopic Pregnancy: A New Role For An Old Drug, M P. Iqbal
Methotrexate As An Alternative To Surgery In Ectopic Pregnancy: A New Role For An Old Drug, M P. Iqbal
Department of Biological & Biomedical Sciences
Abstract is not provided by the author/publisher
Heterogeneity Of Methotrexate Binding In Human Colon Tumor Cells, M P. Iqbal, N Mehboobali, M A. Waqar, M Ahmed
Heterogeneity Of Methotrexate Binding In Human Colon Tumor Cells, M P. Iqbal, N Mehboobali, M A. Waqar, M Ahmed
Department of Biological & Biomedical Sciences
[3H]-methotrexate binding at pH 5.0 and pH 7.2 by the cytosol of tumor tissues and the surrounding normal areas of the gastrointestinal tract of patients suffering from colon or gastric cancer has been used to identify in these cells the presence of a binder of methotrexate having low-affinity for this drug in addition to the enzyme dihydrofolate reductase. Scatchard analysis of the [3H]-methotrexate binding data by a colon tumor sample also reveals that there are two binders of this drug present in the cytosol of these cells. The association constant (Kass) for one binder of methotrexate is = 5.6 x …