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Neuroscience Underlying Temporal Cue Discrimination In The Auditory Cortex, Samantha D. Rosicke
Neuroscience Underlying Temporal Cue Discrimination In The Auditory Cortex, Samantha D. Rosicke
Honors Scholar Theses
Animals, including rats and humans, use the auditory cortex to discriminate auditory cues for communication and survival. It has been shown that individual neurons in the A1, ventral auditory field (VAF), and suprarhinal auditory field (SRAF) of the rat auditory cortex respond to different noise burst lengths to help the rat comprehend an auditory stimulus. In this experiment, we demonstrate the behavioral ability of male Long Evans rats to discriminate between noise bursts of different temporal lengths: 12 ms and 66 ms, in a Two-Alternative Forced Choice task. The study of temporal cue discrimination in the auditory cortex can be …
Neurostructural Organization And Neocortical Projecting Neuron Distribution In A Mouse Model Of Timothy Syndrome-Mediated Autism Spectrum Disorder, Aiden L. Ford
Honors Scholar Theses
Aims: This study investigates the nuanced effect of the CACNA1C mutation on neurocognition and neurodevelopment via an extended study of the Timothy Syndrome (TS) mediated Autism Spectrum Disorder (ASD) mouse model – TS2-neo. It includes: (1) an expanded assessment of the TS2-neo behavioral phenotype, and (2) a comprehensive histological analysis of cortical structural and laminar features.
Methods: 24 age-matched male mice – 12 TS2-neo (B6.Cg-Cacna1ctm2Itl, knock-in G406R mutation), 12 WT (C57BL/6J) – were tested on paradigms examining motor, socio-communicative and cognitive abilities. Neural tissue was processed for either volumetric analysis through Nissl stain (8 TS2-neo, 8 WT) or …