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The Influence Of Preovulatory Estradiol On Uterine Transcriptomics And Proteomics Around Maternal Recognition Of Pregnancy In Beef Cattle, Emmalee J. Northrop
The Influence Of Preovulatory Estradiol On Uterine Transcriptomics And Proteomics Around Maternal Recognition Of Pregnancy In Beef Cattle, Emmalee J. Northrop
Electronic Theses and Dissertations
Preovulatory estradiol has been reported to play a crucial role in pregnancy establishment and maintenance, but the mechanism by which estradiol exerts its effects has not been well characterized. Specifically, the interactions between the maternal uterine environment and the developing conceptus can greatly impact pregnancy success or loss. The objective of this dissertation is to determine the effects of preovulatory estradiol exposure on uterine and trophectoderm transcriptomes, and uterine luminal fluid (ULF) protein composition. Beef cows/heifers were synchronized, artificially inseminated (d 0), and grouped into either high (highE2) or low (lowE2) preovulatory estradiol. Uteri were flushed to collect d16 conceptuses …