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Role Of Programmed Proteolysis During Meiosis, Vincent Matthews, G. Valentin Borner Ph.D.
Role Of Programmed Proteolysis During Meiosis, Vincent Matthews, G. Valentin Borner Ph.D.
Undergraduate Research Posters 2013
Meiosis is the process which forms gametes and spores for reproduction in eukaryotic cells. During the pachytene phase of meiosis I, a protein structure, called the Synaptonemal Complex (SC), forms between homologous chromosomes and creates a scaffold for genetic recombination. In yeast, the Zip1 protein is a major structural component of the SC. At restrictive temperature for meiosis, ZIP1 is required for completion of meiotic divisions. At permissive temperature ZIP1 is required for proper chromosome segregation. We observed that chemical inhibition of the proteasome, with MG132, results in arrest at prophase of meiosis I. Based on these results, we questioned …