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Full-Text Articles in Life Sciences
Extension Of Longevity And Reduction Of Inflammation Is Ovarian-Dependent, But Germ Cell-Independent In Post-Reproductive Female Mice, Tracy L. Habermehl, Kate C. Parkinson, Gene B. Hubbard, Yuji Ikeno, Jennifer I. Engelmeyer, Björn Schumacher, Jeffrey B. Mason
Extension Of Longevity And Reduction Of Inflammation Is Ovarian-Dependent, But Germ Cell-Independent In Post-Reproductive Female Mice, Tracy L. Habermehl, Kate C. Parkinson, Gene B. Hubbard, Yuji Ikeno, Jennifer I. Engelmeyer, Björn Schumacher, Jeffrey B. Mason
Animal, Dairy, and Veterinary Science Faculty Publications
Cardiovascular disease, rare in premenopausal women, increases sharply at menopause and is typically accompanied by chronic inflammation. Previous work in our laboratory demonstrated that replacing senescent ovaries in post-reproductive mice with young, actively cycling ovaries restored many health benefits, including decreased cardiomyopathy and restoration of immune function. Our objective here was to determine if depletion of germ cells from young transplanted ovaries would alter the ovarian-dependent extension of life and health span. Sixty-day-old germ cell-depleted and germ cell-containing ovaries were transplanted to post-reproductive, 17-month-old mice. Mean life span for female CBA/J mice is approximately 644 days. Mice that received germ …
Orthotopic Ovarian Transplantation Procedures To Investigate The Life- And Health-Span Influence Of Ovarian Senescence In Female Mice, Jeffrey B. Mason, Kate C. Parkinson, Tracy L. Habermehl
Orthotopic Ovarian Transplantation Procedures To Investigate The Life- And Health-Span Influence Of Ovarian Senescence In Female Mice, Jeffrey B. Mason, Kate C. Parkinson, Tracy L. Habermehl
Animal, Dairy, and Veterinary Science Faculty Publications
Ovarian transplantation was first conducted at Utah State University in 1963. In more recent work, heterochronic transplantation of mammalian ovaries is being used to investigate the health-protective effects of young ovaries in young females. The current procedures employ an orthotopic transplantation method, where allogenic ovaries are transplanted back to their original position in the ovarian bursa. This is in contrast to the more commonly used heterotopic transplantation of ovaries/ovarian tissue subcutaneously or under the kidney capsule. All three locations provide efficient revascularization of the transplanted tissues. However, orthotopic transplantation provides the ovary with the most natural signaling environment and is …