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Hypoxia-Inducible Factor 2-Alpha Participates In The Regulation Of Intersegmental Vessels Angiogenesis And Neuromast Deposition, Chi-Fu Chou, Han-Jia Lin, Chih-Yu Tsai, Tzung-Yi Lin, Hsin-Yu Chung, Chia-Yin Chiang, Chung-Hao Li, Tun-Wen Pai, Chin-Hwa Hu, Wen-Shyong Tzou
Hypoxia-Inducible Factor 2-Alpha Participates In The Regulation Of Intersegmental Vessels Angiogenesis And Neuromast Deposition, Chi-Fu Chou, Han-Jia Lin, Chih-Yu Tsai, Tzung-Yi Lin, Hsin-Yu Chung, Chia-Yin Chiang, Chung-Hao Li, Tun-Wen Pai, Chin-Hwa Hu, Wen-Shyong Tzou
Journal of Marine Science and Technology
Subtle morphogenesis begins during trunk development after the segmentation period in zebrafish. Sprouting angiogenesis forms the trunk vascular system after the extension of the dorsal aorta and cardinal veins. The posterior lateral line primordium migrates from head to tail, forming the sensory organs on the skin. It is still unclear whether this morphogenesis requires several master regulators to control the ongoing process. Hypoxia-inducible factor 2-alpha (Hif2-alpha) plays an essential role in the maturation of both central neural system and digestive system during embryogenesis. We hypothesized that Hif2-alpha also regulates trunk development. Through loss-of-function experiments, we found that Hif2- alpha, but …