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Microglia Respond To Both Permanent And Temporary Deaferentation In The Adult Zebrafish Olfactory Bulb, Amanda K. Mckenna
Microglia Respond To Both Permanent And Temporary Deaferentation In The Adult Zebrafish Olfactory Bulb, Amanda K. Mckenna
Masters Theses
The major goal of this study was to investigate a microglial response following deafferentation in the adult zebrafish, Danio rerio, olfactory bulb. Microglia were identified in the olfactory bulb using the 4c4 antibody and phagocytic-dependent labeling (DiA). Microglia responded to both methods of deafferentation namely, permanent (cautery) and temporary (Triton X- 100). On one and three days following both permanent and temporary deafferentation there was a significant increase in microglia in the treated olfactory bulb. At five and seven days after permanent and temporary deafferentation there was no longer a significant difference between the treated and untreated olfactory bulbs, …