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Full-Text Articles in Life Sciences
Basal Diet Determined Long-Term Composition Of The Gut Microbiome And Mouse Phenotype To A Greater Extent Than Fecal Microbiome Transfer From Lean Or Obese Human Donors, Daphne Michelle Rodriguez Jimenez, Abby D. Benninghoff, Niklas D.J. Aardema, Sumira Phatak, Korry J. Hintze
Basal Diet Determined Long-Term Composition Of The Gut Microbiome And Mouse Phenotype To A Greater Extent Than Fecal Microbiome Transfer From Lean Or Obese Human Donors, Daphne Michelle Rodriguez Jimenez, Abby D. Benninghoff, Niklas D.J. Aardema, Sumira Phatak, Korry J. Hintze
Animal, Dairy, and Veterinary Science Faculty Publications
The Western dietary pattern can alter the gut microbiome and cause obesity and metabolic disorders. To examine the interactions between diet, the microbiome, and obesity, we transplanted gut microbiota from lean or obese human donors into mice fed one of three diets for 22 weeks: (1) a control AIN93G diet; (2) the total Western diet (TWD), which mimics the American diet; or (3) a 45% high-fat diet-induced obesity (DIO) diet. We hypothesized that a fecal microbiome transfer (FMT) from obese donors would lead to an obese phenotype and aberrant glucose metabolism in recipient mice that would be exacerbated by consumption …
Impact Of Basal Diet On Obesity Phenotype Of Recipient Mice Following Fecal Microbiome Transfer From Obese Or Lean Human Donors, Daphne Michelle Rodriguez Jimenez
Impact Of Basal Diet On Obesity Phenotype Of Recipient Mice Following Fecal Microbiome Transfer From Obese Or Lean Human Donors, Daphne Michelle Rodriguez Jimenez
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
The composition of the gut microbiome can be affected by environmental factors, such as diet. The Western dietary pattern is associated with microbiome dysbiosis and adverse health outcomes, including obesity and metabolic disorders. The objective of this study was to examine the effect of gut microbiota from lean or obese human donors on metabolism and weight gain in recipient mice fed one of three basal diets: 1) the standard AIN93G diet, which promotes rodent health; 2) the total Western diet (TWD), which mimics the American dietary pattern and promotes inflammation-associated colorectal carcinogenesis; and 3) a 45% high fat diet-induced obesity …