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Effects Of Ketoconazole On Uterine Weight And On Unbound Serum Estradiol Relative To Vaginal Cornification In Rats, Leonard L. Hall
Effects Of Ketoconazole On Uterine Weight And On Unbound Serum Estradiol Relative To Vaginal Cornification In Rats, Leonard L. Hall
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Ketoconazole is a broad-spectrum antifungal with oral activity and is documented to block steroid biosynthesis in fungi and mammals.
Estradiol-primed ovariectomized rats lose the estradiol-induced, cornified layer of the vaginal epithelium as a result of ketoconazole treatment. This effect is not explained by current knowledge of ketoconazole's mechanism of action.
Ketoconazole's effect on estradiol's binding to either receptors in target tissues (target-cell receptors) or serum-estradiol-carrying proteins in the aforementioned rats was investigated.
The uterus is responsive to estradiol treatment, which causes an increase in uterine size and weight. This tissue is a sensitive means of studying the effects of ketoconazole …