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Full-Text Articles in Life Sciences
Polybrominated Diphenyl Ethers And Organochlorine Pesticides In Human Milk From Massachusetts, Usa, Kathleen Arcaro, B. Johnson-Restrepo, R. Addink, C. Wong, K. Kannan
Polybrominated Diphenyl Ethers And Organochlorine Pesticides In Human Milk From Massachusetts, Usa, Kathleen Arcaro, B. Johnson-Restrepo, R. Addink, C. Wong, K. Kannan
Kathleen Arcaro
Concentrations of polybrominated diphenyl ethers (PBDEs), and organochlorine pesticides (OCPs; DDTs, HCHs, CHLs, and HCB) were measured in human breast milk samples collected across Massachusetts, USA, in 2004. Seventeen PBDE congeners were found in the samples, ranging in concentration from 0.06 to 1910 ng g(-1) lipid wt. BDE-47 (2,2',4,4'-tetraBDE), BDE-99 (2,2',4,4',5-pentaBDE), and BDE-100 (2,2',4,4',6-pentaBDE) were the major congeners detected in breast milk samples. Overall mean (+/-SD) concentrations of DDTs, HCHs, CHLs, and HCB were 64.5 +/- 75, 18.9 +/- 19, 32.4 +/- 36, and 2.3 +/- 2.2 ng g(-1) lipid wt, respectively. Concentrations of PBDEs were strongly correlated with concentrations …
Pld1 Is Overexpressed In An Er-Negative Mcf-7 Cell Line Variant And A Subset Of Phospho-Akt-Negative Breast Carcinomas, Kathleen Arcaro, J.M. Gozgit, B.T. Pentecost, S.A. Marconi, C.N. Otis
Pld1 Is Overexpressed In An Er-Negative Mcf-7 Cell Line Variant And A Subset Of Phospho-Akt-Negative Breast Carcinomas, Kathleen Arcaro, J.M. Gozgit, B.T. Pentecost, S.A. Marconi, C.N. Otis
Kathleen Arcaro
We have used a novel variant of the human oestrogen receptor (ER)-positive MCF-7 cell line, TMX2-28, as a model to study breast cancer. TMX2-28 cells show no detectable levels of mRNA or protein expression for the ER and express basal cytokeratins (CKs) 5, 14, and 17. cDNA microarray comparison between TMX2-28 and its parent cell line, MCF-7, identified 1402 differentially expressed transcripts, one of which was, phospholipase D1 (PLD1). Using real-time RT-PCR, we confirmed that PLD1 mRNA levels are 10-fold higher in TMX2-28 cells than in MCF-7 cells. We next examined PLD1 expression in human breast carcinomas. Phospholipase D1 mRNA …
Roles For Estrogen And Progesterone In Breast Cancer Prevention, D. Joseph Jerry
Roles For Estrogen And Progesterone In Breast Cancer Prevention, D. Joseph Jerry
D. Joseph Jerry
Prevention has long been the holy grail of breast cancer research. The significant reduction in breast cancer risk afforded by a full-term pregnancy early in life suggests the great potential of preventive strategies. In contrast to the risks associated with prolonged exposures, exogenous estrogen and progesterone for short durations can mimic the protective effects of pregnancy in carcinogen-induced mammary tumor models. Rajkumar and coworkers have now demonstrated that these hormones protect mice from mammary tumors initiated by a spectrum of oncogenic alterations that are common in breast cancers. Although differences between rodent models and humans remain, the results reveal that …
Spatial And Temporal Dynamics Of Land Use Impacts On Water Quality In Watershed Systems, Olga Tsvetkova
Spatial And Temporal Dynamics Of Land Use Impacts On Water Quality In Watershed Systems, Olga Tsvetkova
Masters Theses 1911 - February 2014
ABSTRACT SPATIAL AND TEMPORAL DYNAMICS OF LAND USE IMPACTS ON WATER QUALITY IN WATERSHED SYSTEMS SEPTEMBER 2007 OLGA TSVETKOVA, B.S., NOVGOROD STATE UNIVERSITY, RUSSIA M.S., UNIVERSITY OF MASSACHUSETTS AMHERST Directed by: Professor Timothy O. Randhir Predicting land use change and assessing watershed tradeoffs between the watershed system components through system simulation helps to determine future nutrient and sediment load reductions needed to obtain a particular water quality standard. This also helps to examine the tradeoffs among nutrient and sediment load reductions that achieve the same water quality objective. Tradeoff assessment is a useful tool to meet agricultural and urban needs …
Genetic Mapping In Mice Identifies Dmbt1 As A Candidate Modifier Of Breast Cancer Risk, A. C. Blackburn, L. Z. Hills, A. L. Roberts, J. Wang, D. Aud, J Jung, T. Nikolcheva, J. Allard, G. Peltz, C. N. Otis, Q. J. Cao, R. Ricketts, S.P. Mollenhauer, S. P. Naber, D. Malamud, A. Poustka, D. Joseph Jerry
Genetic Mapping In Mice Identifies Dmbt1 As A Candidate Modifier Of Breast Cancer Risk, A. C. Blackburn, L. Z. Hills, A. L. Roberts, J. Wang, D. Aud, J Jung, T. Nikolcheva, J. Allard, G. Peltz, C. N. Otis, Q. J. Cao, R. Ricketts, S.P. Mollenhauer, S. P. Naber, D. Malamud, A. Poustka, D. Joseph Jerry
D. Joseph Jerry
Low-penetrance breast cancer susceptibility alleles seem to play a significant role in breast cancer risk but are difficult to identify in human cohorts. A genetic screen of 176 N2 backcross progeny of two Trp53+/− strains, BALB/c and C57BL/6, which differ in their susceptibility to mammary tumors, identified a modifier of mammary tumor susceptibility in an ∼25-Mb interval on mouse chromosome 7 (designated SuprMam1). Relative to heterozygotes, homozygosity for BALB/c alleles of SuprMam1 significantly decreased mammary tumor latency from 70.7 to 61.1 weeks and increased risk twofold (P = 0.002). Dmbt1 (deleted in malignant brain tumors 1) was identified as a …