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Inhibition Of Nitric Oxide And Soluble Guanylyl Cyclase Signaling Affects Olfactory Neuron Activity In The Moth, Manduca Sexta, Caroline H. Wilson, Thomas A. Christensen, Alan J. Nighorn

Health Sciences and Kinesiology Faculty Articles

Nitric oxide is emerging as an important modulator of many physiological processes including olfaction, yet the function of this gas in the processing of olfactory information remains poorly understood. In the antennal lobe of the moth, Manduca sexta, nitric oxide is produced in response to odor stimulation, and many interneurons express soluble guanylyl cyclase, a well-characterized nitric oxide target. We used intracellular recording and staining coupled with pharmacological manipulation of nitric oxide and soluble guanylyl cyclase to test the hypothesis that nitric oxide modulates odor responsiveness in olfactory interneurons through soluble guanylyl cyclase-dependent pathways. Nitric oxide synthase inhibition resulted …